{"id":"W4391820890","doi":"10.1186/s13148-024-01631-z","title":"Increased CpG methylation at the CDH1 locus in inflamed ileal mucosa of patients with Crohn disease","year":2024,"lang":"en","type":"article","venue":"Clinical Epigenetics","topic":"Inflammatory Bowel Disease","field":"Biochemistry, Genetics and Molecular Biology","cited_by":8,"is_retracted":false,"has_abstract":true,"ca_institutions":"National Research Council Canada","funders":"Institut National de la Santé et de la Recherche Médicale","keywords":"CDH1; Methylation; CpG site; DNA methylation; Epigenetics; Peripheral blood mononuclear cell; Inflammatory bowel disease; Medicine; Pathogenesis; Immunology; Intestinal mucosa; Gastric mucosa; Enhancer; Cancer research; Gastroenterology; Internal medicine; Biology; Disease; Gene; Gene expression; Stomach; Cell; In vitro; Genetics; Cadherin","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0005211931,0.0001828139,0.0001920393,0.00004660229,0.00004942698,0.00002282683,0.0002249046,0.0001698972,0.00008279437],"category_scores_gemma":[0.0007420177,0.0001287617,0.0001604088,0.0001428858,0.0003734794,0.000004750136,0.0001899526,0.0001728609,0.00003229981],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00002866814,"about_ca_system_score_gemma":0.0003084338,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00001228756,"about_ca_topic_score_gemma":0.0001972711,"domain_scores_codex":[0.9981377,0.0003218828,0.000651729,0.000421535,0.0002300389,0.0002371273],"domain_scores_gemma":[0.9987329,0.0001835536,0.0001336629,0.0005878898,0.000143652,0.0002182897],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.002622098,0.0003506032,0.986244,0.0001457111,0.0001158038,0.0001352912,0.00004321104,0.001063667,0.001091592,0.0001224073,0.0007599961,0.007305572],"study_design_scores_gemma":[0.001073502,0.0001595086,0.9902888,0.00004766618,0.00008918047,1.961775e-7,0.000007499041,0.0005750466,0.001554943,0.0002176512,0.005804692,0.0001813481],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9979003,0.0006620376,0.0003206081,0.00009051929,0.0002155513,0.0004619042,0.0001645263,0.00001469655,0.0001698724],"genre_scores_gemma":[0.9988116,0.0001634166,0.00009158785,0.0002171167,0.0001816563,0.00004778408,0.0002967318,0.00003618025,0.0001539412],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.007124224,"threshold_uncertainty_score":0.5250749,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01212569918001012,"score_gpt":0.2924547671121939,"score_spread":0.2803290679321838,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}