{"id":"W4391820890","doi":"10.1186/s13148-024-01631-z","title":"Increased CpG methylation at the CDH1 locus in inflamed ileal mucosa of patients with Crohn disease","year":2024,"lang":"en","type":"article","venue":"Clinical Epigenetics","topic":"Inflammatory Bowel Disease","field":"Biochemistry, Genetics and Molecular Biology","cited_by":8,"is_retracted":false,"has_abstract":true,"ca_institutions":"National Research Council Canada","funders":"Institut National de la Santé et de la Recherche Médicale","keywords":"CDH1; Methylation; CpG site; DNA methylation; Epigenetics; Peripheral blood mononuclear cell; Inflammatory bowel disease; Medicine; Pathogenesis; Immunology; Intestinal mucosa; Gastric mucosa; Enhancer; Cancer research; Gastroenterology; Internal medicine; Biology; Disease; Gene; Gene expression; Stomach; Cell; In vitro; Genetics; Cadherin","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001233813,0.0001618611,0.0002445331,0.0005427923,0.0002220527,0.000238889,0.0000844185,0.0002623724,0.001390618],"category_scores_gemma":[0.0007122977,0.0001071064,0.00008561419,0.0002888393,0.0001871273,0.0001261476,0.0001386286,0.0002073093,0.0001296742],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00009893098,"about_ca_system_score_gemma":0.0000568373,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004919249,"about_ca_topic_score_gemma":0.0005582,"domain_scores_codex":[0.9998924,0.00002319788,0.00001336958,0.00003334196,0.00001965413,0.00001802596],"domain_scores_gemma":[0.9996541,0.0000882475,0.0001434111,0.00001681989,0.00003208937,0.00006551778],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.0006052492,0.00002535094,0.9804547,0.00003551794,0.0000303315,0.0003900241,0.0001514288,0.00003625935,0.01440287,0.000008766316,0.00006202691,0.00379724],"study_design_scores_gemma":[0.000009901866,0.0001748367,0.9964356,0.000006031707,0.00002525686,0.001744607,0.00009837472,0.00009282141,0.001258074,0.00001588487,0.0001364412,0.000002174724],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9995487,0.0002202895,0.00005042681,0.00001194098,0.000002034786,0.000001662369,0.00004689242,0.000002642456,0.0001153657],"genre_scores_gemma":[0.9997646,0.00005817643,0.00006420216,0.000008566731,0.00000400816,0.000001615459,0.00004851657,8.214361e-7,0.00004942778],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001390618,"threshold_uncertainty_score":0.004652023,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01212569918001012,"score_gpt":0.2924547671121939,"score_spread":0.2803290679321838,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}