{"id":"W4391839232","doi":"10.1002/adhm.202302331","title":"Patient‐Derived Organoids as Therapy Screening Platforms in Cancer Patients","year":2024,"lang":"en","type":"review","venue":"Advanced Healthcare Materials","topic":"Cancer Cells and Metastasis","field":"Medicine","cited_by":25,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of British Columbia","funders":"Terasaki Institute for Biomedical Innovation; National Center for Advancing Translational Sciences; National Institutes of Health; National Cancer Institute; National Heart, Lung, and Blood Institute; National Institute of General Medical Sciences; National Science and Technology Council","keywords":"Organoid; Cancer therapy; Cancer; Medicine; Oncology; Intensive care medicine; Internal medicine; Psychology; Neuroscience","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow","insufficient_payload"],"consensus_categories":[],"category_scores_codex":[0.0002154875,0.0007770452,0.003229655,0.0004498784,0.00008150935,0.0000621546,0.0001627883,0.0004554655,0.0009273468],"category_scores_gemma":[0.00005402264,0.0005459321,0.0003431959,0.0006673843,0.0000485144,0.00014244,0.0001328236,0.000538943,0.0001715696],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0007272876,"about_ca_system_score_gemma":0.0009728361,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0019874,"about_ca_topic_score_gemma":0.0002425509,"domain_scores_codex":[0.9961621,0.0001073231,0.001572837,0.0009093774,0.0004778366,0.0007705669],"domain_scores_gemma":[0.9983517,0.0000538461,0.0005629145,0.0005472605,0.0001843552,0.0002999551],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.000236409,0.00009438743,0.00002040871,0.03202496,0.0001662553,0.00007735859,0.0002932186,3.055485e-7,0.0003760696,0.00002729533,0.0001691942,0.9665141],"study_design_scores_gemma":[0.001339922,0.0008824494,0.00002219645,0.04524449,0.0003711469,0.00002204631,0.00007178434,4.093011e-8,0.002700613,0.00008657807,0.9487305,0.0005282596],"study_design_candidate":"design_other","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.03067825,0.9612247,0.000001533743,0.0001647944,0.002912053,0.003562021,0.001283607,0.0001194291,0.00005357676],"genre_scores_gemma":[0.001508349,0.9934628,0.0004146943,0.0008955075,0.0004047543,0.001242486,0.001610009,0.0002621609,0.0001992217],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.9659859,"threshold_uncertainty_score":0.9999859,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.07507864585574411,"score_gpt":0.4178867419247519,"score_spread":0.3428080960690078,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}