{"id":"W4391840946","doi":"10.1021/jacs.3c09033","title":"Mechanism of Action and Design of Potent Antibacterial Block Copolymer Nanoparticles","year":2024,"lang":"en","type":"article","venue":"Journal of the American Chemical Society","topic":"Antimicrobial agents and applications","field":"Chemistry","cited_by":34,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Victoria","funders":"Canada Foundation for Innovation; Natural Sciences and Engineering Research Council of Canada; Government of Canada; British Columbia Knowledge Development Fund; University of Victoria","keywords":"Nanoparticle; Antibacterial activity; Chemistry; Copolymer; Dispersity; Nanofiber; Crystallinity; Polymer; Nanotechnology; Chemical engineering; Materials science; Polymer chemistry; Organic chemistry; Bacteria; Crystallography","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00008903974,0.00006840055,0.0001927006,0.000006226992,0.00003117159,0.00001328921,0.0001377286,0.00003306443,0.00003505082],"category_scores_gemma":[0.00001246197,0.00004372543,0.0002103915,0.0001120126,0.0002588222,0.00003745818,0.00005842993,0.0001339076,3.899115e-7],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00002791743,"about_ca_system_score_gemma":0.00004384323,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00002172169,"about_ca_topic_score_gemma":4.850068e-8,"domain_scores_codex":[0.9994152,0.00001161224,0.0002761308,0.00007546521,0.0001363409,0.00008525166],"domain_scores_gemma":[0.9994145,0.00005678368,0.0003524104,0.00008992571,0.00004824446,0.00003813198],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00003239279,0.00006064521,0.00003490213,0.00004938263,0.0001200948,3.17097e-7,0.0001320395,0.000007852658,0.9967018,0.00009163149,0.001247519,0.001521473],"study_design_scores_gemma":[0.0001231997,0.00002209346,0.00004863372,0.00007521362,0.0001123995,0.00003508836,0.0001744581,0.0003328714,0.9984543,0.0003169567,0.0002586966,0.00004610224],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9982083,0.0001085206,0.0009163913,0.000642451,0.00005258409,0.00002613619,0.00001298165,0.000005928083,0.00002668708],"genre_scores_gemma":[0.9978705,0.0002019719,0.001690999,0.00006034296,0.0001288024,6.446134e-7,3.807862e-7,0.000008606872,0.00003774163],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001752537,"threshold_uncertainty_score":0.1783071,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01732894235990839,"score_gpt":0.2569757008175597,"score_spread":0.2396467584576513,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}