{"id":"W4391840946","doi":"10.1021/jacs.3c09033","title":"Mechanism of Action and Design of Potent Antibacterial Block Copolymer Nanoparticles","year":2024,"lang":"en","type":"article","venue":"Journal of the American Chemical Society","topic":"Antimicrobial agents and applications","field":"Chemistry","cited_by":34,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Victoria","funders":"Canada Foundation for Innovation; Natural Sciences and Engineering Research Council of Canada; Government of Canada; British Columbia Knowledge Development Fund; University of Victoria","keywords":"Nanoparticle; Antibacterial activity; Chemistry; Copolymer; Dispersity; Nanofiber; Crystallinity; Polymer; Nanotechnology; Chemical engineering; Materials science; Polymer chemistry; Organic chemistry; Bacteria; Crystallography","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001787772,0.0002925101,0.0001855446,0.000175476,0.0001308019,0.0002179836,0.0001855846,0.0003131602,0.0004578579],"category_scores_gemma":[0.0001320945,0.0001665849,0.0001652768,0.00006305698,0.000150625,0.0002100547,0.000112661,0.0003172607,0.0003377395],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0005145476,"about_ca_system_score_gemma":0.0002486449,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002850205,"about_ca_topic_score_gemma":0.000362418,"domain_scores_codex":[0.9999218,0.00001214931,0.000006932542,0.00001873876,0.00002257284,0.00001791402],"domain_scores_gemma":[0.9999409,0.00001030791,0.00001687912,0.000005645579,0.00001035465,0.00001584836],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00002328768,0.00002415921,0.00006242014,0.00003989943,0.000001858224,0.00001960312,0.000006589063,0.0005666334,0.9965984,0.0003568566,0.00003097421,0.002269251],"study_design_scores_gemma":[0.00001826888,0.0002082856,0.000405994,0.000003953297,0.000004884455,0.00006178628,0.000003379907,0.003350909,0.9936795,0.00007788678,0.002181472,0.000003666433],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.961412,0.004958609,0.02920123,0.0003075819,0.00004334753,0.0002513981,0.0001955229,0.0002254433,0.003404964],"genre_scores_gemma":[0.9750383,0.001915967,0.02060307,0.00008721535,0.00001663242,0.0001772885,0.0001664906,0.00002447435,0.00197052],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0005145476,"threshold_uncertainty_score":0.003733337,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01732894235990839,"score_gpt":0.2569757008175597,"score_spread":0.2396467584576513,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}