{"id":"W4391841411","doi":"10.1002/ana.26885","title":"Microglial Reactivity Correlates with Presynaptic Loss Independent of β‐Amyloid and Tau","year":2024,"lang":"en","type":"article","venue":"Annals of Neurology","topic":"Neuroinflammation and Neurodegeneration Mechanisms","field":"Neuroscience","cited_by":15,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"Canadian Institutes of Health Research; National Institutes of Health; H. Lundbeck A/S; Servier; Eisai; China Postdoctoral Science Foundation; Genentech; IXICO; National Natural Science Foundation of China; Northern California Institute for Research and Education; Pfizer; Novartis Pharmaceuticals Corporation; University of Southern California; Biogen; Eli Lilly and Company; Bristol-Myers Squibb; University of California, San Diego; BioClinica; U.S. Department of Defense; Alzheimer's Disease Neuroimaging Initiative; Meso Scale Diagnostics; National Institute on Aging; Alzheimer's Association","keywords":"TREM2; Cerebrospinal fluid; Microglia; Biomarker; Medicine; Internal medicine; Neuroprotection; Endocrinology; Immunology; Oncology; Inflammation; Biology","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003805767,0.0003504495,0.0002157445,0.0005107168,0.0003071727,0.0004197761,0.0002290555,0.0002681073,0.001527171],"category_scores_gemma":[0.000844533,0.0002441141,0.0002512052,0.000363033,0.0002312955,0.0003080072,0.0003109284,0.0003084886,0.0003190362],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001855146,"about_ca_system_score_gemma":0.0001621845,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001560711,"about_ca_topic_score_gemma":0.002313125,"domain_scores_codex":[0.9998479,0.00002494863,0.00001598913,0.00005368637,0.00003145974,0.00002599443],"domain_scores_gemma":[0.9991037,0.00006810176,0.0005795217,0.00007630337,0.00009097028,0.00008130202],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.001834849,0.0001228845,0.9339813,0.00006978391,0.0001578576,0.001082908,0.0001874398,0.0001446755,0.05568023,0.00006167454,0.0001801816,0.00649625],"study_design_scores_gemma":[0.000005245861,0.0001045185,0.9970827,0.000005397991,0.00002276754,0.001106721,0.00004409736,0.0001674058,0.00133151,0.00005209534,0.00007489313,0.000002731085],"study_design_candidate":"bench_or_experimental","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9991517,0.0003106424,0.0001135304,0.00001799095,0.000002538295,0.0000036863,0.0001025532,0.000008628314,0.0002887542],"genre_scores_gemma":[0.9993716,0.0001173611,0.0001361113,0.00001012968,0.000004881491,0.000005061649,0.00009700217,0.000002988906,0.0002548297],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001560711,"threshold_uncertainty_score":0.005108833,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.04329310094433234,"score_gpt":0.2865461585215342,"score_spread":0.2432530575772019,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}