{"id":"W4391845009","doi":"10.1002/adma.202310043","title":"In Vivo Stimulation of Therapeutic Antigen‐Specific T Cells in an Artificial Lymph Node Matrix","year":2024,"lang":"en","type":"article","venue":"Advanced Materials","topic":"Immunotherapy and Immune Responses","field":"Immunology and Microbiology","cited_by":20,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"National Institute of Biomedical Imaging and Bioengineering; National Institute of Allergy and Infectious Diseases; Johns Hopkins University; Natural Sciences and Engineering Research Council of Canada; Achievement Rewards for College Scientists Foundation; National Cancer Institute; National Institutes of Health; National Science Foundation","keywords":"Antigen; T cell; Priming (agriculture); Antigen-presenting cell; Cytotoxic T cell; Immune system; Cell biology; CD28; Biology; Materials science; Ex vivo; Tumor microenvironment; CD8; In vivo; Immunology; In vitro; Biochemistry","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001183022,0.0003313819,0.0001173875,0.000113961,0.00005743167,0.0001837494,0.0001469183,0.0002348354,0.0007437153],"category_scores_gemma":[0.00007989525,0.00009580029,0.0001289696,0.00007723746,0.0001307516,0.0001734611,0.0001610996,0.0002708208,0.0002096255],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001216263,"about_ca_system_score_gemma":0.000134458,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001143147,"about_ca_topic_score_gemma":0.0002373294,"domain_scores_codex":[0.999927,0.00001552053,0.000004048591,0.00001824423,0.00002098733,0.00001419765],"domain_scores_gemma":[0.9999437,0.00001382019,0.00002079986,0.000004631693,0.00000404835,0.00001297883],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0000360759,0.00001355609,0.00001837758,0.00002170547,0.000001109308,0.00001882145,0.000004974679,0.0001172426,0.9993504,0.00005927021,0.00001421704,0.0003443069],"study_design_scores_gemma":[0.00002682249,0.0004355346,0.0003195879,0.000003700835,0.00000769498,0.0000850925,0.000007364566,0.002436551,0.9950249,0.00003623964,0.001613559,0.000002909776],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9868796,0.0008631353,0.009899912,0.00007985829,0.00008057072,0.00007937017,0.0001677498,0.00009083551,0.001858971],"genre_scores_gemma":[0.9882946,0.0003399879,0.009721599,0.0000330557,0.00001651936,0.00008560303,0.00007781084,0.00001471728,0.00141607],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0007437153,"threshold_uncertainty_score":0.002487957,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01699153922538551,"score_gpt":0.2962895826866535,"score_spread":0.279298043461268,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}