{"id":"W4391845009","doi":"10.1002/adma.202310043","title":"In Vivo Stimulation of Therapeutic Antigen‐Specific T Cells in an Artificial Lymph Node Matrix","year":2024,"lang":"en","type":"article","venue":"Advanced Materials","topic":"Immunotherapy and Immune Responses","field":"Immunology and Microbiology","cited_by":20,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"National Institute of Biomedical Imaging and Bioengineering; National Institute of Allergy and Infectious Diseases; Johns Hopkins University; Natural Sciences and Engineering Research Council of Canada; Achievement Rewards for College Scientists Foundation; National Cancer Institute; National Institutes of Health; National Science Foundation","keywords":"Antigen; T cell; Priming (agriculture); Antigen-presenting cell; Cytotoxic T cell; Immune system; Cell biology; CD28; Biology; Materials science; Ex vivo; Tumor microenvironment; CD8; In vivo; Immunology; In vitro; Biochemistry","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["insufficient_payload"],"consensus_categories":[],"category_scores_codex":[0.0004428835,0.0001673302,0.0003531289,0.000286654,0.00003691473,0.00003057902,0.0001449784,0.0001803655,0.002286841],"category_scores_gemma":[0.00001179788,0.0001539701,0.0000443047,0.0002179778,0.00009192499,0.0003421497,0.00002206167,0.00008156601,0.0001799334],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00006408735,"about_ca_system_score_gemma":0.0000558863,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00007146059,"about_ca_topic_score_gemma":0.000009430887,"domain_scores_codex":[0.9985111,0.000336711,0.0005654929,0.0002670465,0.00003925655,0.0002803564],"domain_scores_gemma":[0.9994767,0.0001459823,0.00008371015,0.0002539103,0.00003313872,0.000006500906],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.001667349,0.0001268438,0.00007474234,0.00004046665,0.00002366362,0.00001081521,0.0006800111,0.0004018442,0.9907272,0.001285363,0.00001764955,0.004944069],"study_design_scores_gemma":[0.0007344832,0.00009912824,0.00321869,0.0001174814,0.000004290553,0.000007323571,0.0001266739,0.000008273325,0.9860309,0.001120022,0.008372716,0.0001600268],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.986701,0.01053859,0.0001589936,0.00004333539,0.002117942,0.0002680304,0.00007899595,0.00004942953,0.00004366094],"genre_scores_gemma":[0.9981611,0.001203834,0.0001488802,0.00004190692,0.00002741868,0.00002438658,0.00003467371,0.00002839975,0.0003294149],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.01146006,"threshold_uncertainty_score":0.9986252,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01699153922538551,"score_gpt":0.2962895826866535,"score_spread":0.279298043461268,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}