{"id":"W4391846685","doi":"10.1007/s13139-024-00842-9","title":"Radionuclide Imaging of the Neuroanatomical and Neurochemical Substrate of Cognitive Decline in Parkinson’s Disease","year":2024,"lang":"en","type":"review","venue":"Nuclear Medicine and Molecular Imaging","topic":"Parkinson's Disease Mechanisms and Treatments","field":"Medicine","cited_by":3,"is_retracted":false,"has_abstract":false,"ca_institutions":"University of Manitoba; Health Sciences Centre","funders":"Natural Sciences and Engineering Research Council of Canada; Parkinson Canada; Parkinson Society Canada; University of Manitoba","keywords":"Neurochemical; Positron emission tomography; Medicine; Cognitive decline; Parkinson's disease; Cognition; Neuroinflammation; Neuroscience; Disease; Neuroimaging; Cognitive deficit; Dementia; Cognitive impairment; Pathology; Psychology; Internal medicine; Psychiatry; Nuclear medicine","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.0001764748,0.0003914378,0.001274804,0.0002836088,0.00003169659,0.00001391581,0.0001174505,0.00006325816,0.00001588093],"category_scores_gemma":[0.0003447728,0.0002471987,0.000276914,0.0003138076,0.0004269643,0.00003725039,0.0002443278,0.0004578262,0.000001813727],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00003302544,"about_ca_system_score_gemma":0.0001560553,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00004162528,"about_ca_topic_score_gemma":9.088287e-7,"domain_scores_codex":[0.9980944,0.000133031,0.0006140958,0.0005693395,0.0003400498,0.0002490274],"domain_scores_gemma":[0.9990188,0.0001155706,0.0002235636,0.0002885424,0.00005599495,0.000297538],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.0007047933,0.0008372474,0.01856903,0.05532315,0.001051412,0.01532562,0.0007688022,1.580093e-7,0.001910008,0.001399652,0.001071017,0.9030391],"study_design_scores_gemma":[0.007455532,0.0002074412,0.01516311,0.1532973,0.02695669,0.001769411,0.0004456206,0.001860859,0.0001199109,0.001192236,0.7907123,0.0008195582],"study_design_candidate":"design_other","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.0496561,0.9478663,0.000007317743,0.001489772,0.0001030617,0.0006123118,0.00004550648,0.00002065546,0.0001990246],"genre_scores_gemma":[0.3121527,0.6865746,0.000054765,0.001056417,0.00003781701,0.00001207148,0.00003072305,0.00007634189,0.000004508266],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.9022195,"threshold_uncertainty_score":0.999998,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01879393666640469,"score_gpt":0.3109929692996009,"score_spread":0.2921990326331962,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}