{"id":"W4391847514","doi":"10.1172/jci.insight.176044","title":"Increasing Sufu gene dosage reveals its unorthodox role in promoting polydactyly and medulloblastoma tumorigenesis","year":2024,"lang":"en","type":"article","venue":"JCI Insight","topic":"Hedgehog Signaling Pathway Studies","field":"Biochemistry, Genetics and Molecular Biology","cited_by":4,"is_retracted":false,"has_abstract":true,"ca_institutions":"Hospital for Sick Children; University of Toronto","funders":"National Natural Science Foundation of China; National Science Foundation","keywords":"GLI1; Sonic hedgehog; Medulloblastoma; Carcinogenesis; GLI3; PTCH1; Hedgehog; Cancer research; Suppressor; Polydactyly; Biology; Hedgehog signaling pathway; Patched; Gene; Cell biology; Gene expression; Genetics","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001070327,0.0001950386,0.0001676075,0.0004064409,0.0001250926,0.0001981421,0.0001109127,0.0001609258,0.0008020347],"category_scores_gemma":[0.0001117819,0.0001186417,0.0001517827,0.0001914446,0.000235271,0.0001403059,0.0001945282,0.0002910646,0.0001001145],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001969699,"about_ca_system_score_gemma":0.0001359683,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0007628378,"about_ca_topic_score_gemma":0.002241082,"domain_scores_codex":[0.9998764,0.00001731566,0.00001150841,0.00003004435,0.00003182651,0.00003291568],"domain_scores_gemma":[0.9999106,0.00001824327,0.00003074795,0.00001267975,0.000004041997,0.00002361446],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00006002815,0.000009395267,0.001330189,0.000008395015,0.000003259737,0.00003516748,0.000007938802,0.00002538351,0.9975364,0.00004209494,0.000009907909,0.0009318571],"study_design_scores_gemma":[0.000006846015,0.0003268876,0.07758509,0.000003345055,0.00002086111,0.0004030878,0.00005265711,0.0006258136,0.9197308,0.00006106578,0.001179448,0.000004155563],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9972456,0.0007580337,0.001213067,0.00004050016,0.000006085336,0.000007006885,0.0001757372,0.00003496763,0.000519096],"genre_scores_gemma":[0.9982395,0.0003528588,0.0007353514,0.00001846645,0.000003133238,0.000008924038,0.0001448266,0.000005943704,0.0004910958],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0008020347,"threshold_uncertainty_score":0.002683103,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01180374285166211,"score_gpt":0.2513509853587156,"score_spread":0.2395472425070535,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}