{"id":"W4391847912","doi":"10.1016/j.isci.2024.109233","title":"Mtb HLA-E-tetramer-sorted CD8+ T cells have a diverse TCR repertoire","year":2024,"lang":"en","type":"article","venue":"iScience","topic":"Immune Cell Function and Interaction","field":"Immunology and Microbiology","cited_by":7,"is_retracted":false,"has_abstract":true,"ca_institutions":"Institute of Infection and Immunity","funders":"H2020 Marie Skłodowska-Curie Actions; National Institute of Allergy and Infectious Diseases; Bill and Melinda Gates Foundation; Leids Universitair Medisch Centrum; National Institutes of Health; Istituto Superiore di Sanità; Stichting voor de Technische Wetenschappen; Nederlandse Organisatie voor Wetenschappelijk Onderzoek","keywords":"T-cell receptor; CD8; Repertoire; Cytotoxic T cell; Human leukocyte antigen; Biology; Tetramer; Immunology; T cell; Cell biology; Chemistry; Immune system; Antigen; Genetics; Biochemistry","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["insufficient_payload"],"consensus_categories":["insufficient_payload"],"category_scores_codex":[0.0001727508,0.0001293331,0.0001208839,0.0001402228,0.00027194,0.00007965793,0.0002150618,0.0001255213,0.00430769],"category_scores_gemma":[0.00005347899,0.0001057149,0.00009910764,0.0002486146,0.0002913573,0.0003326731,0.00007900687,0.0003216746,0.007440582],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00005727106,"about_ca_system_score_gemma":0.00006301908,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001616072,"about_ca_topic_score_gemma":0.000009152307,"domain_scores_codex":[0.9990042,0.00006472648,0.0001886897,0.0003976064,0.00005013487,0.0002945951],"domain_scores_gemma":[0.9995519,0.00007955874,0.00004004324,0.0002573588,0.00004930584,0.00002183789],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"not_applicable","study_design_scores_codex":[0.00002370124,0.00003903176,0.00006061792,0.000008580213,0.00002286978,0.0000182632,0.0006349008,0.000007907558,0.9138548,0.000270702,0.06234536,0.02271323],"study_design_scores_gemma":[0.0001762356,0.0001092602,0.000540241,0.00005090952,0.00001958666,0.0001039899,0.0009669338,0.0003175515,0.3408507,0.00002852119,0.656685,0.0001510869],"study_design_candidate":"bench_or_experimental","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.8605019,0.01050301,0.003334938,0.001206128,0.04520867,0.0003990919,0.0000189628,0.0007992039,0.07802804],"genre_scores_gemma":[0.8291561,0.0000995028,0.00002788267,0.0003711586,0.00003388831,0.000007408986,0.0000175661,0.000008327194,0.1702781],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.5943397,"threshold_uncertainty_score":0.9966025,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01607030229557717,"score_gpt":0.2486877381143289,"score_spread":0.2326174358187518,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}