{"id":"W4391847912","doi":"10.1016/j.isci.2024.109233","title":"Mtb HLA-E-tetramer-sorted CD8+ T cells have a diverse TCR repertoire","year":2024,"lang":"en","type":"article","venue":"iScience","topic":"Immune Cell Function and Interaction","field":"Immunology and Microbiology","cited_by":7,"is_retracted":false,"has_abstract":true,"ca_institutions":"Institute of Infection and Immunity","funders":"H2020 Marie Skłodowska-Curie Actions; National Institute of Allergy and Infectious Diseases; Bill and Melinda Gates Foundation; Leids Universitair Medisch Centrum; National Institutes of Health; Istituto Superiore di Sanità; Stichting voor de Technische Wetenschappen; Nederlandse Organisatie voor Wetenschappelijk Onderzoek","keywords":"T-cell receptor; CD8; Repertoire; Cytotoxic T cell; Human leukocyte antigen; Biology; Tetramer; Immunology; T cell; Cell biology; Chemistry; Immune system; Antigen; Genetics; Biochemistry","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00009171483,0.0001670446,0.0001547927,0.0002140195,0.0001526347,0.0002537078,0.00008795659,0.0002293954,0.001645714],"category_scores_gemma":[0.0001339292,0.00007232383,0.00006963046,0.0001538998,0.0001078587,0.0001154983,0.0001096492,0.0002888223,0.000531267],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00005068777,"about_ca_system_score_gemma":0.00004298399,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001405279,"about_ca_topic_score_gemma":0.0002559408,"domain_scores_codex":[0.9998928,0.00001434289,0.00001194145,0.0000426657,0.00001883899,0.00001941873],"domain_scores_gemma":[0.9999167,0.00002612247,0.0000144938,0.00001401357,0.00001160431,0.00001712888],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00004213207,0.000007603466,0.00068308,0.000007417344,0.000001640613,0.00001732651,0.00001642803,0.00001398754,0.9982544,0.000008595724,0.000008397133,0.0009389431],"study_design_scores_gemma":[0.00001969498,0.0003323214,0.05205607,0.000009461476,0.00002234608,0.001543032,0.0001366998,0.001461243,0.9411644,0.0001790921,0.003067627,0.000007837393],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.996121,0.0002325053,0.002581787,0.0000226676,0.000005564171,0.00001181824,0.000231855,0.00002962179,0.000763184],"genre_scores_gemma":[0.994761,0.0001404476,0.003238781,0.00006390984,0.000007761104,0.00002155501,0.0006129091,0.00003074651,0.00112294],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001645714,"threshold_uncertainty_score":0.005505443,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01607030229557717,"score_gpt":0.2486877381143289,"score_spread":0.2326174358187518,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}