{"id":"W4391848401","doi":"10.1016/j.jcyt.2024.01.013","title":"Source of hematopoietic progenitor cells determines their capacity to generate innate lymphoid cells ex vivo","year":2024,"lang":"en","type":"article","venue":"Cytotherapy","topic":"IL-33, ST2, and ILC Pathways","field":"Immunology and Microbiology","cited_by":1,"is_retracted":false,"has_abstract":true,"ca_institutions":"Institute of Infection and Immunity","funders":"Nederlandse Organisatie voor Wetenschappelijk Onderzoek; Amsterdam University Medical Centers; ZonMw; Landsteiner Foundation for Blood Transfusion Research","keywords":"Ex vivo; Progenitor cell; Innate lymphoid cell; Haematopoiesis; Immunology; Stem cell; Bone marrow; Stromal cell; Mucositis; Hematopoietic stem cell transplantation; Cancer research; CD34; Biology; Medicine; In vivo; Innate immune system; Immune system; Radiation therapy; Cell biology; Internal medicine","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow","insufficient_payload"],"consensus_categories":[],"category_scores_codex":[0.0002055939,0.0003308895,0.0004424331,0.0001687098,0.0001247399,0.00003930481,0.0003236234,0.0002744904,0.0003589061],"category_scores_gemma":[0.000008821412,0.0002592939,0.0001860928,0.0002987386,0.0002015409,0.00007860233,0.00005166398,0.0001703583,0.0008820336],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00004986393,"about_ca_system_score_gemma":0.0001172338,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00006588969,"about_ca_topic_score_gemma":0.00001716347,"domain_scores_codex":[0.9984558,0.0001611773,0.000392126,0.0004579269,0.0000515849,0.0004814062],"domain_scores_gemma":[0.9992474,0.00009673055,0.00008527513,0.0004248944,0.00009358622,0.0000521513],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00009070295,0.00009680149,0.00008463213,0.0001336838,0.0001715143,0.000006849559,0.005791763,0.00001552936,0.9860929,0.0001080663,0.00433917,0.003068364],"study_design_scores_gemma":[0.0004281795,0.0001987054,0.00001355308,0.00006631903,0.00001745045,0.00005227401,0.0001244761,0.00002305395,0.7631776,0.0001130721,0.2355531,0.0002321391],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9918497,0.002659373,0.001082638,0.00006027796,0.00234341,0.0004438687,0.0008796817,0.0001902733,0.0004907774],"genre_scores_gemma":[0.9927803,0.0003196807,0.0002911662,0.000450233,0.0002332369,0.00005210418,0.00001494146,0.00007386503,0.005784436],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.231214,"threshold_uncertainty_score":0.9999859,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01661238794148261,"score_gpt":0.2221013918446657,"score_spread":0.2054890039031831,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}