{"id":"W4391850604","doi":"10.1016/j.cels.2024.01.009","title":"Widespread alteration of protein autoinhibition in human cancers","year":2024,"lang":"en","type":"article","venue":"Cell Systems","topic":"Signaling Pathways in Disease","field":"Biochemistry, Genetics and Molecular Biology","cited_by":1,"is_retracted":false,"has_abstract":false,"ca_institutions":"Canada's Michael Smith Genome Sciences Centre; University of British Columbia","funders":"National Research Foundation of Korea; Canadian Institutes of Health Research; National Research Foundation; Genome Canada","keywords":"Allosteric regulation; Biology; Missense mutation; Cancer; Genetics; Mutation; Interactome; Transcriptome; Cancer cell; Computational biology; Gene; Receptor; Gene expression","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001156704,0.0001469012,0.0002086126,0.0006673622,0.0001962189,0.000304415,0.0001460085,0.0001523173,0.001312163],"category_scores_gemma":[0.0002379143,0.0001166784,0.0001230911,0.0004676273,0.0002820583,0.0001312246,0.0002578815,0.0002222249,0.0002379464],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001931089,"about_ca_system_score_gemma":0.0001850335,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001109474,"about_ca_topic_score_gemma":0.0009824098,"domain_scores_codex":[0.999889,0.0000164595,0.00001014109,0.00002955615,0.00002617097,0.00002859494],"domain_scores_gemma":[0.9998306,0.00003320941,0.000039624,0.0000380337,0.00002002609,0.00003854322],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0003337141,0.00002150796,0.01189122,0.00004442139,0.00002677026,0.0005109247,0.00005715396,0.0002168692,0.9771055,0.0006980244,0.0001111632,0.008982736],"study_design_scores_gemma":[0.00001905187,0.0003165803,0.4314311,0.0000103435,0.00009076112,0.00956692,0.0001997357,0.001361648,0.5475574,0.001185454,0.008245348,0.00001575466],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.994458,0.002114248,0.001022386,0.00007768093,0.000008647099,0.000005439021,0.0002207509,0.00009407644,0.001998875],"genre_scores_gemma":[0.9989951,0.0003059479,0.0001267884,0.00001136888,0.000003577815,0.000001893362,0.00008059013,0.000007182858,0.0004675152],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001312163,"threshold_uncertainty_score":0.004389644,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.009521886676855548,"score_gpt":0.2506456722805738,"score_spread":0.2411237856037183,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}