{"id":"W4391850760","doi":"10.1016/j.jmsacl.2024.02.003","title":"Therapeutic drug monitoring of clozapine in human serum by high-throughput paper spray mass spectrometry","year":2024,"lang":"en","type":"article","venue":"Journal of Mass Spectrometry and Advances in the Clinical Lab","topic":"Mass Spectrometry Techniques and Applications","field":"Chemistry","cited_by":8,"is_retracted":false,"has_abstract":true,"ca_institutions":"Fraser Health; Simon Fraser University; University of Victoria; Vancouver Island University","funders":"Natural Sciences and Engineering Research Council of Canada; Vancouver Island University","keywords":"Chromatography; Therapeutic drug monitoring; Mass spectrometry; Analyte; Protein precipitation; Chemistry; Metabolite; Triple quadrupole mass spectrometer; Detection limit; Selected reaction monitoring; Tandem mass spectrometry; Pharmacokinetics; Pharmacology; Medicine","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0009426115,0.0008543513,0.0003749296,0.0007795287,0.0002262,0.000543393,0.0005163301,0.0008032454,0.001223991],"category_scores_gemma":[0.001634386,0.0002309079,0.0004319645,0.0005536624,0.0003551199,0.0003137923,0.0003206545,0.0004611351,0.000800651],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003590687,"about_ca_system_score_gemma":0.0006059882,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0008737202,"about_ca_topic_score_gemma":0.001016937,"domain_scores_codex":[0.9985368,0.0003427594,0.00005904308,0.0001876638,0.0008259577,0.00004775631],"domain_scores_gemma":[0.999377,0.0001644614,0.000170688,0.00005187953,0.0002050826,0.00003092676],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0003215334,0.00005454264,0.004607178,0.000188035,0.00007326528,0.0001476431,0.00006156501,0.0002601211,0.9701402,0.0001050643,0.0003935037,0.02364743],"study_design_scores_gemma":[0.00005138128,0.0008537908,0.02037074,0.00005507877,0.0001180319,0.002121929,0.00006904532,0.00612178,0.9644812,0.0002350163,0.005488584,0.00003339387],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.7394495,0.01762252,0.2294132,0.0006444627,0.0004385346,0.000662762,0.001966441,0.00336043,0.006442108],"genre_scores_gemma":[0.8736406,0.007278063,0.1115875,0.0006267684,0.0001894202,0.0004376721,0.001671086,0.0001103628,0.004458474],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001223991,"threshold_uncertainty_score":0.004985094,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01868511370540028,"score_gpt":0.3550468759952622,"score_spread":0.336361762289862,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}