{"id":"W4391870195","doi":"10.1016/s1474-4422(24)00027-9","title":"Clinical trials for progressive multiple sclerosis: progress, new lessons learned, and remaining challenges","year":2024,"lang":"en","type":"article","venue":"The Lancet Neurology","topic":"Multiple Sclerosis Research Studies","field":"Medicine","cited_by":63,"is_retracted":false,"has_abstract":false,"ca_institutions":"University of Manitoba","funders":"","keywords":"Multiple sclerosis; Clinical trial; Remyelination; Medicine; Disease; Intensive care medicine; Expanded Disability Status Scale; Pathology; Psychiatry; Internal medicine","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaresearch"],"consensus_categories":[],"category_scores_codex":[0.006190108,0.0002213825,0.001222104,0.00008757688,0.0001923485,0.00007501728,0.0002293654,0.0001935137,0.00002030216],"category_scores_gemma":[0.01177294,0.0001279542,0.0002272863,0.0001284843,0.0007084524,0.0000618382,0.00026541,0.000812358,0.00002077942],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00001058732,"about_ca_system_score_gemma":0.0001605576,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000008094546,"about_ca_topic_score_gemma":0.00003850584,"domain_scores_codex":[0.9965889,0.001201945,0.000616396,0.0006906827,0.0002480888,0.000653933],"domain_scores_gemma":[0.9906734,0.008375639,0.0001517019,0.0005025102,0.00009687179,0.0001998809],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.003759556,0.00009550404,0.008852645,0.000477268,0.0005553258,0.00006729754,0.0009496089,0.000001944756,0.0007068909,0.002590906,0.02815096,0.9537921],"study_design_scores_gemma":[0.01653744,0.005783951,0.3709923,0.00125647,0.0007143017,0.0002342644,0.0004394493,0.01152924,0.000343424,0.005514388,0.5861984,0.0004563015],"study_design_candidate":"design_other","study_design_consensus":null,"genre_codex":"commentary","genre_gemma":"empirical","genre_scores_codex":[0.1407676,0.1267319,0.0001233837,0.7274447,0.0008061943,0.00322588,0.00005751191,0.0004328442,0.0004100723],"genre_scores_gemma":[0.9262254,0.0640043,0.001488147,0.002142393,0.005144812,0.0006939982,0.00001145087,0.00006502944,0.000224495],"genre_candidate":"empirical","genre_consensus":null,"teacher_disagreement_score":0.9533358,"threshold_uncertainty_score":0.9965513,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.7178297648655821,"score_gpt":0.5358146476112376,"score_spread":0.1820151172543445,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}