{"id":"W4391873217","doi":"10.1093/jcag/gwad061.252","title":"A252 DRUG DISCONTINUATION AND PERSISTENT SYMPTOMS AMONG THE USERS OF BIOSIMILAR AND LEGACY ANTI-TNF DRUGS IN A REAL-WORLD CANADIAN IBD COHORT","year":2024,"lang":"en","type":"article","venue":"Journal of the Canadian Association of Gastroenterology","topic":"Biosimilars and Bioanalytical Methods","field":"Immunology and Microbiology","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"Hamilton Health Sciences; University of British Columbia; McGill University; University of Manitoba","funders":"Canadian Institutes of Health Research","keywords":"Biosimilar; Discontinuation; Cohort; Medicine; Drug; Infliximab; Tumor necrosis factor alpha; Pharmacology; Internal medicine","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":true,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001035606,0.0004326548,0.000629743,0.001399272,0.001977082,0.001365396,0.001116411,0.0006339877,0.002066157],"category_scores_gemma":[0.002601383,0.0003452147,0.0009773546,0.002709232,0.0005709633,0.0004096323,0.0006769842,0.000752285,0.0002210285],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.007922265,"about_ca_system_score_gemma":0.007808618,"about_ca_topic_candidate":true,"about_ca_topic_consensus":true,"about_ca_topic_score_codex":0.9237792,"about_ca_topic_score_gemma":0.8904595,"domain_scores_codex":[0.9986369,0.0001210237,0.00008299875,0.0003252875,0.0004533314,0.0003804912],"domain_scores_gemma":[0.9972349,0.0001828735,0.001047054,0.0001495802,0.0007686014,0.0006170434],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.0001298929,0.0000230376,0.9981813,0.00001445962,0.00005085236,0.00006277631,0.0001985258,0.00002771569,0.0001212459,0.000013449,0.0002283759,0.0009484651],"study_design_scores_gemma":[0.00001080308,0.00004023589,0.9992139,0.000008048821,0.00002802761,0.00009165383,0.000216227,0.0001178544,0.00002217084,0.000004771384,0.000239233,0.000007166434],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9966799,0.0003788343,0.00004107318,0.00008380063,0.000004204803,0.00002707592,0.002245649,0.000003606072,0.0005359822],"genre_scores_gemma":[0.9979717,0.0002393989,0.00006442479,0.00005435422,0.000007235599,0.00001718928,0.001378224,0.000002845929,0.0002645987],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.07622081,"threshold_uncertainty_score":0.1533393,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.007170871140938479,"score_gpt":0.23317791886817,"score_spread":0.2260070477272315,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}