{"id":"W4391873217","doi":"10.1093/jcag/gwad061.252","title":"A252 DRUG DISCONTINUATION AND PERSISTENT SYMPTOMS AMONG THE USERS OF BIOSIMILAR AND LEGACY ANTI-TNF DRUGS IN A REAL-WORLD CANADIAN IBD COHORT","year":2024,"lang":"en","type":"article","venue":"Journal of the Canadian Association of Gastroenterology","topic":"Biosimilars and Bioanalytical Methods","field":"Immunology and Microbiology","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"Hamilton Health Sciences; University of British Columbia; McGill University; University of Manitoba","funders":"Canadian Institutes of Health Research","keywords":"Biosimilar; Discontinuation; Cohort; Medicine; Drug; Infliximab; Tumor necrosis factor alpha; Pharmacology; Internal medicine","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":true,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001963824,0.0001169465,0.0003864804,0.0004662041,0.0001126187,0.00003789336,0.0002054437,0.0001584631,0.00003694386],"category_scores_gemma":[0.0001896491,0.00007474185,0.0001665116,0.000208414,0.0003340061,0.0001155879,0.00003305644,0.0004426487,4.39186e-7],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0005400199,"about_ca_system_score_gemma":0.0003314279,"about_ca_topic_candidate":true,"about_ca_topic_consensus":true,"about_ca_topic_score_codex":0.1989446,"about_ca_topic_score_gemma":0.9552454,"domain_scores_codex":[0.99827,0.000657458,0.0005261365,0.0001371372,0.00007907245,0.0003301378],"domain_scores_gemma":[0.9989923,0.0002064725,0.000447819,0.0001197486,0.0001322667,0.0001014031],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.00003932536,0.00001354228,0.9943976,0.00001292459,0.0005380476,0.000003432466,0.0006625989,0.000007994317,0.0005065793,0.0002010043,0.00327748,0.0003394504],"study_design_scores_gemma":[0.0005469071,0.0001790934,0.9956869,0.0001203687,0.0003050111,0.00002821573,0.0004601244,0.000079621,0.0002138388,0.00006677322,0.002262935,0.00005018941],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9656796,0.0004000546,0.000001521556,0.03290249,0.0005914313,0.0001639393,0.00006563085,0.00000194061,0.0001933396],"genre_scores_gemma":[0.9985639,0.0001798354,0.00002678776,0.0006152059,0.00002895547,0.000001749964,0.00000339813,0.000007965617,0.0005721672],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.7563008,"threshold_uncertainty_score":0.8063897,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.007170871140938479,"score_gpt":0.23317791886817,"score_spread":0.2260070477272315,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}