{"id":"W4391873223","doi":"10.1093/jcag/gwad061.188","title":"A188 ENHANCED MICROBIAL TRYPTOPHAN METABOLISM ACTIVATES THE ARYL HYDROCARBON RECEPTOR AND AMELIORATES INTESTINAL INFLAMMATION","year":2024,"lang":"en","type":"article","venue":"Journal of the Canadian Association of Gastroenterology","topic":"Diet and metabolism studies","field":"Medicine","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"McMaster University","funders":"Canadian Institutes of Health Research","keywords":"Aryl hydrocarbon receptor; Tryptophan; Chemistry; Inflammation; Metabolism; Receptor; Biochemistry; Microbiology; Biology; Amino acid; Immunology","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00009787786,0.0003910345,0.000414371,0.0004462892,0.0001005792,0.0002834706,0.0002228022,0.0002748697,0.003294935],"category_scores_gemma":[0.00009689035,0.0001255435,0.0003161827,0.0001912086,0.0002317759,0.0001815804,0.0001780695,0.0008826799,0.0007137977],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001570893,"about_ca_system_score_gemma":0.0002105903,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0005011922,"about_ca_topic_score_gemma":0.0007227341,"domain_scores_codex":[0.9998754,0.00002236707,0.0000134039,0.00001910994,0.00003538814,0.00003435249],"domain_scores_gemma":[0.9998524,0.00001229287,0.00004768975,0.00001417115,0.00001429413,0.0000590861],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.001323109,0.0002104595,0.0001882708,0.00007783624,0.00001454639,0.00003695968,0.000009876016,0.00004551155,0.9956216,0.00005415898,0.0001396242,0.002277917],"study_design_scores_gemma":[0.0004717211,0.01169795,0.01348156,0.00004228382,0.0001147826,0.0003998009,0.0001168011,0.0008245363,0.9636021,0.0001578333,0.009069761,0.00002081971],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9924883,0.002337644,0.001889947,0.0002276777,0.0001308249,0.00005045606,0.001182414,0.0002823307,0.001410422],"genre_scores_gemma":[0.9893169,0.001823079,0.001789759,0.0001622675,0.00004612796,0.00008355499,0.001463776,0.00004774579,0.005266869],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.003294935,"threshold_uncertainty_score":0.01102269,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.006418122454757877,"score_gpt":0.2236466303612533,"score_spread":0.2172285079064954,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}