{"id":"W4391873344","doi":"10.1093/jcag/gwad061.016","title":"A16 ALTERATIONS TO BOTH INTESTINAL BARRIER INTEGRITY AND THE MICROBIOTA CONSPIRE DURING AGING TO PROMOTE DISEASE PROGRESSION IN A MOUSE MODEL OF MULTIPLE SCLEROSIS","year":2024,"lang":"en","type":"article","venue":"Journal of the Canadian Association of Gastroenterology","topic":"Gut microbiota and health","field":"Biochemistry, Genetics and Molecular Biology","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Toronto; University of British Columbia","funders":"","keywords":"Multiple sclerosis; Disease; Medicine; Immunology; Biology; Pathology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":true,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00036665,0.0006658124,0.0004305023,0.000804525,0.0002358665,0.0004731437,0.0003104077,0.0008046646,0.002422454],"category_scores_gemma":[0.0001538492,0.0003473556,0.000568292,0.0002566702,0.000396567,0.0005126152,0.0002773886,0.001618221,0.0005791843],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000338075,"about_ca_system_score_gemma":0.000312673,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0007014718,"about_ca_topic_score_gemma":0.001264201,"domain_scores_codex":[0.9996068,0.00006306508,0.00005842855,0.0000960285,0.00008330675,0.00009246878],"domain_scores_gemma":[0.9995313,0.00002360859,0.0001708598,0.00005006936,0.00004137585,0.000182911],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0008936971,0.0002643625,0.000650417,0.00005402562,0.00001533929,0.00009279104,0.00004142959,0.00006070516,0.9965437,0.0001082129,0.00009702564,0.001178314],"study_design_scores_gemma":[0.0002874786,0.01094949,0.0505595,0.0001111131,0.0001944011,0.001711552,0.0003641904,0.002421564,0.9241679,0.0004278613,0.008767857,0.00003707748],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9937322,0.001463252,0.001913873,0.0002818777,0.0001239145,0.00006293293,0.001113501,0.000146264,0.001162183],"genre_scores_gemma":[0.9849383,0.00121626,0.003492951,0.0002647384,0.0000361912,0.0001884541,0.0009604027,0.00005784578,0.008844852],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002422454,"threshold_uncertainty_score":0.008103907,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01187378855236765,"score_gpt":0.2450163440373702,"score_spread":0.2331425554850026,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}