{"id":"W4391873372","doi":"10.1093/jcag/gwad061.176","title":"A176 RESTORATION OF IMPAIRED MICROBIOTA-MEDIATED ARYL HYDROCARBON RECEPTOR SIGNALING IN PATIENTS WITH CELIAC DISEASE BY ORAL TRYPTOPHAN SUPPLEMENTATION: AN EXPLORATORY STUDY","year":2024,"lang":"en","type":"article","venue":"Journal of the Canadian Association of Gastroenterology","topic":"Celiac Disease Research and Management","field":"Medicine","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"McMaster University","funders":"","keywords":"Aryl hydrocarbon receptor; Disease; Medicine; Tryptophan; Chemistry; Internal medicine; Biochemistry; Transcription factor; Gene","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001230178,0.0007908888,0.001308558,0.000346164,0.0006315377,0.0005842277,0.0005174887,0.0008838776,0.00363359],"category_scores_gemma":[0.0006287534,0.0003083707,0.001277276,0.0002960886,0.0007539632,0.0005151218,0.0004074261,0.000772182,0.0005575231],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0005267795,"about_ca_system_score_gemma":0.0007770756,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0008520798,"about_ca_topic_score_gemma":0.001076866,"domain_scores_codex":[0.9995627,0.0001736642,0.00003263303,0.00009475262,0.00003596638,0.0001002707],"domain_scores_gemma":[0.9994861,0.00009872595,0.00007289321,0.00006587639,0.00005750533,0.0002188289],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"nonrandomized_trial","study_design_scores_codex":[0.6518039,0.145327,0.06132047,0.002014946,0.001812789,0.001592113,0.0007996385,0.0002962335,0.06953939,0.0002246774,0.0009866875,0.06428228],"study_design_scores_gemma":[0.08751657,0.7800656,0.122579,0.00007812313,0.001442368,0.0005350863,0.0004164976,0.0003742076,0.00428863,0.0001604509,0.00249926,0.00004419715],"study_design_candidate":"nonrandomized_trial","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9978514,0.0009705197,0.000141376,0.00005558488,0.00002222561,0.0005002115,0.0001167263,0.000008378755,0.000333521],"genre_scores_gemma":[0.9975111,0.000462971,0.0003685689,0.0001781525,0.00006872479,0.0004777391,0.0001893786,0.000002353526,0.0007409342],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.00363359,"threshold_uncertainty_score":0.01215559,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.007974389952635429,"score_gpt":0.2437586064042069,"score_spread":0.2357842164515715,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}