{"id":"W4391873443","doi":"10.1093/jcag/gwad061.257","title":"A257 EARLY PROACTIVE THERAPEUTIC DRUG MONITORING WITH USTEKINUMAB THERAPY IN PAEDIATRIC CROHN’S DISEASE","year":2024,"lang":"en","type":"article","venue":"Journal of the Canadian Association of Gastroenterology","topic":"Inflammatory Bowel Disease","field":"Biochemistry, Genetics and Molecular Biology","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Manitoba; London Health Sciences Centre; University of Alberta; University of Calgary; Dalhousie University; Hospital for Sick Children","funders":"","keywords":"Ustekinumab; Crohn's disease; Medicine; Drug; Disease; Crohn disease; Therapeutic drug monitoring; Intensive care medicine; Internal medicine; Pharmacology; Adalimumab","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":true,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001169178,0.0002564917,0.0006493884,0.0004736236,0.0002644017,0.000946612,0.0003860089,0.0002992044,0.001438723],"category_scores_gemma":[0.002467782,0.0001694129,0.0004950655,0.0008753147,0.0002555909,0.0003749605,0.0003489253,0.0004174741,0.0002770213],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0007675042,"about_ca_system_score_gemma":0.001077995,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.006523763,"about_ca_topic_score_gemma":0.008845247,"domain_scores_codex":[0.9989453,0.0003904711,0.0001059763,0.0001476699,0.0002826715,0.0001279158],"domain_scores_gemma":[0.9979613,0.000403697,0.00103433,0.00008281771,0.0002306835,0.000287274],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.002084363,0.0001059875,0.9624177,0.0001760112,0.0001180915,0.0003567538,0.0001022292,0.0002629038,0.0011769,0.00005941877,0.001046387,0.03209334],"study_design_scores_gemma":[0.0001296418,0.001256533,0.9927766,0.00009796076,0.0001272622,0.001210288,0.000124467,0.0006705591,0.0008386087,0.00006723371,0.002691322,0.000009370933],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9922733,0.004742216,0.0002662964,0.0001880405,0.00002992163,0.00003632107,0.0007241677,0.00002329046,0.001716511],"genre_scores_gemma":[0.9974664,0.001110916,0.0005015214,0.00008401222,0.00002628188,0.00002689533,0.0005161957,0.000005078364,0.0002626187],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.006523763,"threshold_uncertainty_score":0.01297158,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.005450648132429025,"score_gpt":0.2120571535725941,"score_spread":0.2066065054401651,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}