{"id":"W4391873696","doi":"10.1093/jcag/gwad061.062","title":"A62 EXAMINING THE ACTIVATION OF XENOBIOTIC RECEPTORS PXR AND AHR IN COLONOIDS USING MICROBIAL METABOLITES AND CHEMICAL LIGANDS","year":2024,"lang":"en","type":"article","venue":"Journal of the Canadian Association of Gastroenterology","topic":"Analytical Methods in Pharmaceuticals","field":"Chemistry","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"Alberta Children's Hospital; University of Calgary","funders":"Canadian Institutes of Health Research","keywords":"Pregnane X receptor; Xenobiotic; Aryl hydrocarbon receptor; Chemistry; Receptor; Environmental chemistry; Biochemistry; Nuclear receptor; Transcription factor; Gene","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001332934,0.00008234731,0.0002922555,0.0001388652,0.00004019268,0.00002416311,0.0001479618,0.0001746684,0.0000391475],"category_scores_gemma":[0.001313124,0.00005835723,0.000065816,0.0001290349,0.0001569633,0.00006989137,0.00004414526,0.0005430787,9.376502e-8],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0005041851,"about_ca_system_score_gemma":0.0001631971,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004174238,"about_ca_topic_score_gemma":0.00191631,"domain_scores_codex":[0.9989119,0.0001786749,0.0004765887,0.00009223255,0.0001428099,0.0001978275],"domain_scores_gemma":[0.9987167,0.0005796756,0.0004359197,0.00007068952,0.0001048657,0.00009219698],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001111139,0.00001783925,0.4107439,0.0000751124,0.0002418949,0.000002414416,0.0004354794,0.00004862587,0.5874578,0.0001301511,0.0002183852,0.0005172783],"study_design_scores_gemma":[0.003395869,0.0003641512,0.1251741,0.001156812,0.001315834,0.0003147614,0.0009338416,0.009313966,0.8531212,0.002403303,0.00224636,0.0002598487],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9957384,0.00009524317,0.00004306433,0.003831139,0.0001966308,0.00003544219,0.00001308704,0.000001602292,0.00004535383],"genre_scores_gemma":[0.9986795,0.00003430591,0.0008806474,0.0002506502,0.0001056575,4.068678e-7,5.688265e-7,0.000008607552,0.00003972039],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.2855698,"threshold_uncertainty_score":0.2379739,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02635493604668724,"score_gpt":0.2971820781289557,"score_spread":0.2708271420822684,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}