{"id":"W4391873696","doi":"10.1093/jcag/gwad061.062","title":"A62 EXAMINING THE ACTIVATION OF XENOBIOTIC RECEPTORS PXR AND AHR IN COLONOIDS USING MICROBIAL METABOLITES AND CHEMICAL LIGANDS","year":2024,"lang":"en","type":"article","venue":"Journal of the Canadian Association of Gastroenterology","topic":"Analytical Methods in Pharmaceuticals","field":"Chemistry","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"Alberta Children's Hospital; University of Calgary","funders":"Canadian Institutes of Health Research","keywords":"Pregnane X receptor; Xenobiotic; Aryl hydrocarbon receptor; Chemistry; Receptor; Environmental chemistry; Biochemistry; Nuclear receptor; Transcription factor; Gene","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001821553,0.0003808707,0.0003338986,0.0003407908,0.0001864702,0.0003468713,0.0001089492,0.0003323364,0.002144974],"category_scores_gemma":[0.000120719,0.0001806045,0.0005532855,0.0003377612,0.0002300452,0.000199716,0.0002187043,0.0006283976,0.0006242308],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002667941,"about_ca_system_score_gemma":0.0002315725,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0008728781,"about_ca_topic_score_gemma":0.001048387,"domain_scores_codex":[0.9997236,0.00003294689,0.00002160089,0.0000784864,0.00009241135,0.00005103576],"domain_scores_gemma":[0.9998415,0.00003232608,0.00004033745,0.00001940256,0.00003264384,0.00003390019],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00005134603,0.000009115121,0.0001755846,0.00002400479,0.000002282739,0.00001262782,0.000004994426,0.00002340797,0.9992542,0.000009237292,0.00001420188,0.0004190989],"study_design_scores_gemma":[0.000009425059,0.0005412351,0.01184347,0.00000861001,0.00002509929,0.00009468759,0.00009645389,0.0005408742,0.984616,0.00003372422,0.002183279,0.00000721343],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9859936,0.002795601,0.006018199,0.0001630233,0.00008021507,0.0000609874,0.002577806,0.0001657334,0.002144845],"genre_scores_gemma":[0.9806678,0.001876036,0.006794658,0.0001918037,0.00001792956,0.0002105766,0.003022752,0.00004896952,0.007169495],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002144974,"threshold_uncertainty_score":0.007175624,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02635493604668724,"score_gpt":0.2971820781289557,"score_spread":0.2708271420822684,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}