{"id":"W4391880766","doi":"10.1080/15548627.2024.2312787","title":"The role of SARS-CoV-2 ORF7a in autophagy flux disruption: implications for viral infection and pathogenesis","year":2024,"lang":"en","type":"article","venue":"Autophagy","topic":"SARS-CoV-2 and COVID-19 Research","field":"Medicine","cited_by":15,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Calgary","funders":"Basic and Applied Basic Research Foundation of Guangdong Province; China Postdoctoral Science Foundation; Chengdu Medical College","keywords":"Autophagy; Biology; Lysosome; Viral pathogenesis; Pathogenesis; Cell biology; Virology; Mechanism (biology); Reprogramming; Viral replication; Virus; Immunology; Genetics; Cell","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003844099,0.0001310894,0.0002106371,0.0001974367,0.0001292345,0.00006024796,0.00009143219,0.000111292,0.000003353967],"category_scores_gemma":[0.0001478357,0.00009756919,0.000114468,0.0004278262,0.0001201793,0.0001148638,0.00006068746,0.0001490888,0.0000222672],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000102374,"about_ca_system_score_gemma":0.0002181292,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003132178,"about_ca_topic_score_gemma":0.0001787817,"domain_scores_codex":[0.9989024,0.00004778563,0.0003058389,0.0003083321,0.0001571423,0.0002785151],"domain_scores_gemma":[0.9992188,0.0003084263,0.00004030079,0.0003141753,0.00009743769,0.00002084549],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0000869175,0.00007844411,0.01193171,0.0001505802,0.00004645157,0.000007032414,0.0002127029,3.969893e-7,0.8252299,0.01282087,0.0001760899,0.1492588],"study_design_scores_gemma":[0.0006822689,0.0002753005,0.1729019,0.00006679718,0.0000619035,0.00006003266,0.00004162857,0.004311902,0.6345079,0.009480699,0.177499,0.0001106461],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.990667,0.005916073,0.0005627708,0.0007181612,0.0001606778,0.0006685772,0.00002972052,0.0000981968,0.001178811],"genre_scores_gemma":[0.9977531,0.00006425068,0.0001203622,0.001370615,0.0001621933,0.0003778449,0.00001018328,0.00002829572,0.0001131625],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.190722,"threshold_uncertainty_score":0.3978756,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03662404847337616,"score_gpt":0.3722668925715877,"score_spread":0.3356428440982115,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}