{"id":"W4391882558","doi":"10.2217/imt-2023-0293","title":"Upadacitinib for the Treatment of Moderate-to-Severe Crohn’s Disease","year":2024,"lang":"en","type":"review","venue":"Immunotherapy","topic":"Inflammatory Bowel Disease","field":"Biochemistry, Genetics and Molecular Biology","cited_by":2,"is_retracted":false,"has_abstract":true,"ca_institutions":"Western University; University of Calgary","funders":"","keywords":"Medicine; Rheumatoid arthritis; Crohn's disease; Internal medicine; Janus kinase; Disease; Oncology; Malignancy; Cytokine","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.00008889708,0.0004459407,0.0005887242,0.00005811621,0.00008804561,0.00005431743,0.0003559479,0.0001771523,0.00002931776],"category_scores_gemma":[0.0000163486,0.0002604549,0.001099273,0.00007243757,0.00006549827,0.000001756714,0.00003138492,0.00005507145,0.00004753203],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00006075158,"about_ca_system_score_gemma":0.0005319996,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000005165929,"about_ca_topic_score_gemma":0.00000550624,"domain_scores_codex":[0.9986992,0.0000701684,0.0004165175,0.0004468656,0.0001140668,0.0002531882],"domain_scores_gemma":[0.9987185,0.00004203773,0.0001390576,0.0009277625,0.00007325365,0.0000993664],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.00147905,0.0001961415,0.000001552194,0.003781246,0.001647357,0.00005783089,0.00008466682,0.00003070818,0.0000606383,0.0002615236,0.002903548,0.9894958],"study_design_scores_gemma":[0.000519663,0.0001947308,0.00004012744,0.0007685706,0.0007952346,0.000003917374,0.000005816473,0.00002055285,0.00002820604,0.00004696715,0.9972808,0.0002953582],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.0004258277,0.9947219,0.0002794257,0.00003702213,0.0003960135,0.002633445,0.001434296,0.00001776142,0.00005423577],"genre_scores_gemma":[0.0000822382,0.992678,0.00009372706,0.0001240266,0.0004322935,0.002088812,0.0004382454,0.0001362643,0.003926366],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.9943773,"threshold_uncertainty_score":0.9999847,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02976364088780458,"score_gpt":0.3346496295131636,"score_spread":0.304885988625359,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}