{"id":"W4391882901","doi":"10.1038/s41386-024-01817-2","title":"Role of the histone variant H2A.Z.1 in memory, transcription, and alternative splicing is mediated by lysine modification","year":2024,"lang":"en","type":"article","venue":"Neuropsychopharmacology","topic":"Genomics and Chromatin Dynamics","field":"Biochemistry, Genetics and Molecular Biology","cited_by":18,"is_retracted":false,"has_abstract":true,"ca_institutions":"Toronto Zoo; University of Ottawa; University of Waterloo; University of Toronto","funders":"Canadian Institutes of Health Research; Canadian Network for Research and Innovation in Machining Technology, Natural Sciences and Engineering Research Council of Canada; National Institute of General Medical Sciences; Natural Sciences and Engineering Research Council of Canada; Government of Canada","keywords":"Histone; Acetylation; Epigenetics; Biology; Genetics; Transcription (linguistics); Histone H2A; Alternative splicing; Gene; Histone methylation; Gene expression; Cell biology; Gene isoform; DNA methylation","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002035316,0.0003392984,0.0001856814,0.0001455647,0.0002098561,0.0004308081,0.0003980793,0.0003055799,0.001063843],"category_scores_gemma":[0.0001086609,0.0001617857,0.0003485677,0.000118176,0.000395112,0.0002820567,0.0003036443,0.0004181915,0.0003576991],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003524112,"about_ca_system_score_gemma":0.0002402971,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001212055,"about_ca_topic_score_gemma":0.001130406,"domain_scores_codex":[0.9998406,0.00001443404,0.00001303157,0.00004971297,0.0000406615,0.00004159267],"domain_scores_gemma":[0.9998707,0.000009944249,0.00005373083,0.00001648777,0.00001827913,0.00003095133],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001096811,0.00001034201,0.0007374132,0.00001509636,0.000007261018,0.00002929164,0.000006872673,0.00003671739,0.9978529,0.000148226,0.00002638809,0.001019791],"study_design_scores_gemma":[0.00001620674,0.0002014145,0.01558821,0.000006896481,0.00002840636,0.000219591,0.00004194626,0.0007709255,0.9811068,0.0001748118,0.001837085,0.000007653201],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9910602,0.002090061,0.004739096,0.0001582034,0.00007404653,0.00001702136,0.0002795121,0.00007691504,0.001504908],"genre_scores_gemma":[0.9968157,0.0004294385,0.0008911174,0.00005943975,0.000008012392,0.00001052558,0.0001944599,0.00001322839,0.001578007],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001212055,"threshold_uncertainty_score":0.003558934,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.006245262935817866,"score_gpt":0.2648697766435424,"score_spread":0.2586245137077246,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}