{"id":"W4391884811","doi":"10.1186/s12864-024-10094-8","title":"In silico prediction of the metabolism of Blastocrithidia nonstop, a trypanosomatid with non-canonical genetic code","year":2024,"lang":"en","type":"article","venue":"BMC Genomics","topic":"Trypanosoma species research and implications","field":"Medicine","cited_by":4,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Alberta","funders":"European Regional Development Fund; Ostravská Univerzita v Ostravě; Agentúra na Podporu Výskumu a Vývoja; Grantová Agentura České Republiky; Ministerstvo Školství, Mládeže a Tělovýchovy; European Commission","keywords":"Biology; NonStop; Genetic code; Genetics; In silico; Trypanosoma brucei; Computational biology; Gene","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001768665,0.0007722364,0.0004178782,0.0003893787,0.0003336774,0.0006949003,0.0002525022,0.0006150476,0.001511419],"category_scores_gemma":[0.0005177431,0.0001781371,0.0006145566,0.0003700933,0.0001241639,0.0002085907,0.0002021387,0.0003267042,0.0005246829],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003777369,"about_ca_system_score_gemma":0.0004884776,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001626138,"about_ca_topic_score_gemma":0.002660876,"domain_scores_codex":[0.9999007,0.00002177078,0.000005664654,0.00004333549,0.00001626928,0.00001229561],"domain_scores_gemma":[0.9998083,0.00009910346,0.00003015276,0.00001111672,0.00002516586,0.00002626506],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"simulation_or_modeling","study_design_scores_codex":[0.004457891,0.00065731,0.1035792,0.002457576,0.0008342007,0.002909146,0.000345903,0.1801209,0.6559371,0.002249224,0.003923815,0.04252786],"study_design_scores_gemma":[0.0001945849,0.001425894,0.044916,0.00007816248,0.0006444615,0.001314264,0.0002880401,0.8024747,0.1358797,0.00227555,0.01044207,0.00006658752],"study_design_candidate":"simulation_or_modeling","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9742464,0.0007342822,0.01599388,0.0001628859,0.00003667974,0.0000377759,0.005928302,0.001086549,0.001773158],"genre_scores_gemma":[0.9425724,0.0004599282,0.03509736,0.00006759065,0.00001079907,0.00004497419,0.020784,0.0001907512,0.0007721515],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001626138,"threshold_uncertainty_score":0.005056202,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02073408940044252,"score_gpt":0.2744475124618708,"score_spread":0.2537134230614282,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}