{"id":"W4391886504","doi":"10.1093/jcag/gwad061.213","title":"A213 DUPILUMAB EFFICACY IN EOSINOPHILIC ESOPHAGITIS PERSISTS FOR HISTOLOGIC, SYMPTOMATIC, AND ENDOSCOPIC OUTCOMES REGARDLESS OF CONCOMITANT HIGH-DOSE PROTON PUMP INHIBITOR USE","year":2024,"lang":"en","type":"article","venue":"Journal of the Canadian Association of Gastroenterology","topic":"Eosinophilic Esophagitis","field":"Medicine","cited_by":1,"is_retracted":false,"has_abstract":true,"ca_institutions":"Sanofi (Canada)","funders":"","keywords":"Eosinophilic esophagitis; Concomitant; Proton-pump inhibitor; Medicine; Dupilumab; Nerd; Gastroenterology; Esophagitis; Internal medicine; Dermatology; GERD; Reflux; Asthma; Disease","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0008574111,0.0002773191,0.000850295,0.0001912804,0.0002665989,0.0006431414,0.0002258339,0.0004544522,0.003395915],"category_scores_gemma":[0.0009589074,0.0001476103,0.0008133755,0.0002526474,0.0002300022,0.0003381635,0.0001985029,0.0006872005,0.0005425947],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003547184,"about_ca_system_score_gemma":0.0004600418,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0005405237,"about_ca_topic_score_gemma":0.001134193,"domain_scores_codex":[0.999582,0.0001482803,0.00004110001,0.00007528247,0.00006662131,0.0000866777],"domain_scores_gemma":[0.999348,0.0001531967,0.0001909599,0.000045278,0.00006794349,0.0001946444],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"observational","study_design_scores_codex":[0.723168,0.008796387,0.06260928,0.0009490703,0.002540235,0.0003114337,0.000107715,0.000971348,0.04680751,0.0001706642,0.003992566,0.1495758],"study_design_scores_gemma":[0.1043072,0.4333508,0.4367064,0.0001433475,0.003085374,0.001056893,0.0001487032,0.00293469,0.01112063,0.0003320023,0.006759609,0.00005432664],"study_design_candidate":"observational","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9950794,0.00232901,0.0001024151,0.000107113,0.00004317646,0.0001237945,0.000660096,0.00002098961,0.001534085],"genre_scores_gemma":[0.9984577,0.000277058,0.0001004442,0.00009170709,0.0000348132,0.0000739033,0.0004587165,0.000002671075,0.0005029749],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.003395915,"threshold_uncertainty_score":0.01136047,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01351028653807159,"score_gpt":0.2522800628325217,"score_spread":0.2387697762944501,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}