{"id":"W4391892192","doi":"10.2139/ssrn.4722048","title":"Impact of Antimicrobials on Penile HIV Susceptibility and Immunology in Uncircumcised Men: A Randomized, Open-Label, Phase I/Ii Clinical Trial","year":2024,"lang":"en","type":"preprint","venue":"SSRN Electronic Journal","topic":"HIV/AIDS Research and Interventions","field":"Medicine","cited_by":1,"is_retracted":false,"has_abstract":false,"ca_institutions":"University Health Network; Western University; University of Toronto","funders":"","keywords":"Open label; Medicine; Human immunodeficiency virus (HIV); Randomized controlled trial; Antimicrobial; Clinical trial; Immunology; Male circumcision; Internal medicine; Biology; Microbiology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001382959,0.002206098,0.003444269,0.0004128119,0.0005544038,0.001332493,0.0008633878,0.002696374,0.009535695],"category_scores_gemma":[0.001869082,0.0007555737,0.001911434,0.0004330899,0.001490124,0.001316486,0.0004658407,0.003008488,0.00101483],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0005857549,"about_ca_system_score_gemma":0.001044662,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0007814498,"about_ca_topic_score_gemma":0.001159003,"domain_scores_codex":[0.9993168,0.0003686987,0.00003100963,0.00013491,0.00004281985,0.0001058348],"domain_scores_gemma":[0.9989328,0.000369455,0.000222847,0.00008435683,0.00006117946,0.0003293437],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"randomized_trial","study_design_scores_codex":[0.9778881,0.009363444,0.0003894938,0.0004705192,0.000575776,0.00002388245,0.00003642382,0.0001471406,0.001303155,0.00005532902,0.0003251814,0.009421497],"study_design_scores_gemma":[0.8837463,0.1139855,0.001008404,0.00004801583,0.0003819713,0.00001782102,0.00002687542,0.0002031177,0.0002297548,0.0001079693,0.0002310259,0.0000131877],"study_design_candidate":"randomized_trial","study_design_consensus":"randomized_trial","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9880779,0.004519768,0.0005937508,0.0006716122,0.0004894632,0.003460856,0.0007520955,0.00008132544,0.001353273],"genre_scores_gemma":[0.9841236,0.003553856,0.00199156,0.001180214,0.0006585807,0.004400892,0.0006953267,0.00002539996,0.003370526],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.009535695,"threshold_uncertainty_score":0.03190011,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.06432748200393927,"score_gpt":0.4669310001070553,"score_spread":0.402603518103116,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}