{"id":"W4391896905","doi":"10.1093/molehr/gaae008","title":"Sperm DNA methylation defects in a new mouse model of the 5,10-methylenetetrahydrofolate reductase <i>677C&amp;gt;T</i> variant and correction with moderate dose folic acid supplementation","year":2024,"lang":"en","type":"article","venue":"Molecular Human Reproduction","topic":"Folate and B Vitamins Research","field":"Medicine","cited_by":8,"is_retracted":false,"has_abstract":true,"ca_institutions":"Aegera Therapeutics (Canada); McGill University; McGill University Health Centre","funders":"Health Canada; Canadian Institutes of Health Research; Genome Canada; McGill University Health Centre; Alliance de recherche numérique du Canada; Fonds Québécois de la Recherche sur la Nature et les Technologies; McGill University","keywords":"Methylenetetrahydrofolate reductase; Biology; DNA methylation; Sperm; Methylation; Genotype; Spermatogenesis; Genetics; Andrology; Endocrinology; Gene; Medicine; Gene expression","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0006024737,0.0001988994,0.0002445853,0.0003249006,0.0001094167,0.00007184903,0.00006406342,0.0001000286,0.00003215174],"category_scores_gemma":[0.00009043517,0.0001507483,0.00008040839,0.0005717517,0.00007781747,0.0002103953,0.00004844738,0.0003123466,0.000004643287],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001537715,"about_ca_system_score_gemma":0.0001944541,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003950846,"about_ca_topic_score_gemma":0.0002223855,"domain_scores_codex":[0.9980837,0.0001607778,0.0003572778,0.0007041661,0.0004502165,0.0002439394],"domain_scores_gemma":[0.9990935,0.00001372174,0.00009092966,0.000596359,0.0001190315,0.00008640509],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0004562497,0.00010596,0.00008661041,0.000178844,0.00006914055,0.0000198104,0.001103832,0.01013608,0.9807026,0.0001948991,0.0003817353,0.006564231],"study_design_scores_gemma":[0.001317046,0.0003460716,0.000714613,0.0001675941,0.0001974556,0.0001241576,0.00005499713,0.03519811,0.9608864,0.0005847113,0.0002416953,0.0001671672],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9928411,0.001030133,0.004166135,0.0005112732,0.0001604777,0.0009100794,0.000008024698,0.00006307547,0.0003097222],"genre_scores_gemma":[0.9936021,0.000119353,0.0008572813,0.00003848065,0.0001099936,0.00003257115,0.0001074221,0.00004815344,0.005084665],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.02506204,"threshold_uncertainty_score":0.6147338,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02813462446756377,"score_gpt":0.3056328534683653,"score_spread":0.2774982290008015,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}