{"id":"W4391896905","doi":"10.1093/molehr/gaae008","title":"Sperm DNA methylation defects in a new mouse model of the 5,10-methylenetetrahydrofolate reductase <i>677C&amp;gt;T</i> variant and correction with moderate dose folic acid supplementation","year":2024,"lang":"en","type":"article","venue":"Molecular Human Reproduction","topic":"Folate and B Vitamins Research","field":"Medicine","cited_by":8,"is_retracted":false,"has_abstract":true,"ca_institutions":"Aegera Therapeutics (Canada); McGill University; McGill University Health Centre","funders":"Health Canada; Canadian Institutes of Health Research; Genome Canada; McGill University Health Centre; Alliance de recherche numérique du Canada; Fonds Québécois de la Recherche sur la Nature et les Technologies; McGill University","keywords":"Methylenetetrahydrofolate reductase; Biology; DNA methylation; Sperm; Methylation; Genotype; Spermatogenesis; Genetics; Andrology; Endocrinology; Gene; Medicine; Gene expression","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0004298038,0.001253854,0.0008659872,0.001860057,0.000592374,0.0005858389,0.0007808655,0.002052105,0.005267192],"category_scores_gemma":[0.0003020997,0.0008811455,0.001279026,0.0006284542,0.0008962614,0.000471177,0.0005112353,0.001886455,0.001177661],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0006552465,"about_ca_system_score_gemma":0.0005113059,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.002259097,"about_ca_topic_score_gemma":0.003342316,"domain_scores_codex":[0.9991991,0.0000823315,0.0001035351,0.0003103936,0.0002054317,0.00009925829],"domain_scores_gemma":[0.9993806,0.00006547388,0.0002465116,0.00007317259,0.00005118691,0.000183042],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0007734874,0.0002274896,0.0005008149,0.00009214994,0.00004977668,0.0005479828,0.0000955647,0.000181949,0.9940922,0.0004991465,0.0002386545,0.002700832],"study_design_scores_gemma":[0.001315524,0.007156251,0.02459882,0.0002191757,0.0006259786,0.009254653,0.0003128712,0.003960099,0.9257439,0.0009584965,0.02572265,0.00013153],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9755681,0.00205018,0.01131897,0.0009603141,0.0002188586,0.0002486569,0.006203134,0.0009974802,0.002434271],"genre_scores_gemma":[0.9393852,0.003540622,0.01633604,0.000617792,0.00009110755,0.0007879275,0.007002888,0.0006102342,0.03162811],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.005267192,"threshold_uncertainty_score":0.01762056,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02813462446756377,"score_gpt":0.3056328534683653,"score_spread":0.2774982290008015,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}