{"id":"W4391898081","doi":"10.1007/s12011-024-04093-9","title":"Grape Seed Proanthocyanidins Protect Pancreatic β Cells Against Ferroptosis via the Nrf2 Pathway in Type 2 Diabetes","year":2024,"lang":"en","type":"article","venue":"Biological Trace Element Research","topic":"Ferroptosis and cancer prognosis","field":"Medicine","cited_by":19,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Victoria","funders":"Xinjiang Production and Construction Corps","keywords":"Chemistry; Reactive oxygen species; Malondialdehyde; Glutathione; GPX4; Superoxide dismutase; Insulin resistance; Pharmacology; Biochemistry; Glutathione peroxidase; Antioxidant; Diabetes mellitus; Endocrinology; Biology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.003247838,0.0002592035,0.0004205967,0.0002423469,0.0002374703,0.0001363705,0.000337967,0.0002066611,0.0004872784],"category_scores_gemma":[0.0002780787,0.0001310069,0.0001705883,0.001626137,0.0003373215,0.0000610033,0.0001850577,0.00108608,0.0002077909],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002807511,"about_ca_system_score_gemma":0.0002195138,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00006021456,"about_ca_topic_score_gemma":0.00002408798,"domain_scores_codex":[0.9963223,0.0007420364,0.0004471094,0.0007016431,0.0007857882,0.001001125],"domain_scores_gemma":[0.9986839,0.0004936971,0.00003516583,0.0004162479,0.0001933497,0.0001776773],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0004714566,0.0009961525,0.06625194,0.0006599556,0.0002387967,0.0001071734,0.0005344987,0.000008372737,0.8193284,0.0005217569,0.00186307,0.1090185],"study_design_scores_gemma":[0.00192428,0.009811097,0.1614537,0.001603831,0.00007829451,0.000008179609,0.001903496,0.004674686,0.6686398,0.0006817534,0.14847,0.0007509454],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9822577,0.007264392,0.00001699273,0.005939639,0.0001524945,0.003080306,0.0000163637,0.0001353871,0.001136708],"genre_scores_gemma":[0.99418,0.003236593,0.0001869705,0.0002191825,0.0002611156,0.001459057,0.00003059027,0.00003094062,0.0003955735],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.1506886,"threshold_uncertainty_score":0.5342305,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.1082061689720024,"score_gpt":0.3603279563664226,"score_spread":0.2521217873944202,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}