{"id":"W4391898851","doi":"10.1186/s13046-024-02966-4","title":"Tumorigenesis of basal muscle invasive bladder cancer was mediated by PTEN protein degradation resulting from SNHG1 upregulation","year":2024,"lang":"en","type":"article","venue":"Journal of Experimental & Clinical Cancer Research","topic":"Cancer-related molecular mechanisms research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":6,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"National Natural Science Foundation of China; School of Medicine, New York University; York University; Wenzhou Medical University","keywords":"PTEN; Downregulation and upregulation; Gene knockdown; Cancer research; Tensin; Carcinogenesis; Malignant transformation; Biology; Ectopic expression; Cell growth; Cell biology; Cell culture; Molecular biology; Cancer; Gene; Signal transduction; PI3K/AKT/mTOR pathway; Biochemistry; Genetics","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001010175,0.0003445359,0.0001765605,0.0002561634,0.0002074034,0.0001929882,0.0001402634,0.0001829754,0.001223371],"category_scores_gemma":[0.00007628725,0.0001391629,0.0003326712,0.0001963571,0.0002367109,0.0001258094,0.0002669015,0.0004217877,0.0002581486],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002553704,"about_ca_system_score_gemma":0.0003224116,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0009228587,"about_ca_topic_score_gemma":0.001672461,"domain_scores_codex":[0.9998907,0.000008797195,0.000007963353,0.00002556066,0.00003770779,0.00002929516],"domain_scores_gemma":[0.9999367,0.000004935895,0.00002198225,0.000006517128,0.000007291615,0.00002258115],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0000653309,0.00001192417,0.0005378225,0.00004107558,0.000004942794,0.00007234279,0.00001150273,0.00003182829,0.9983982,0.00005833059,0.00004135378,0.0007251862],"study_design_scores_gemma":[0.000007553055,0.000200626,0.01286128,0.000005854455,0.00002771731,0.0003664833,0.0000337766,0.0009199373,0.9836272,0.0000529055,0.001892114,0.000004543861],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9922768,0.001243511,0.004261689,0.0001224594,0.00004670388,0.00003491017,0.0006052055,0.0002056098,0.001203101],"genre_scores_gemma":[0.9955036,0.0007464734,0.00115307,0.00005452469,0.000004891481,0.00002958519,0.0005858483,0.00001593483,0.001906113],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001223371,"threshold_uncertainty_score":0.004092634,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0861954293883173,"score_gpt":0.4625818497291023,"score_spread":0.376386420340785,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}