{"id":"W4391915303","doi":"10.1002/chem.202303699","title":"3‐Oxidopyridinium Ions Are Versatile Bioorthogonal Dipoles for Use in Cycloadditions with Cyclooctynes","year":2024,"lang":"en","type":"article","venue":"Chemistry - A European Journal","topic":"Click Chemistry and Applications","field":"Chemistry","cited_by":3,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Ottawa","funders":"","keywords":"Bioorthogonal chemistry; Ion; Dipole; Chemistry; Combinatorial chemistry; Nanotechnology; Computational chemistry; Materials science; Organic chemistry; Click chemistry","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow","insufficient_payload"],"consensus_categories":[],"category_scores_codex":[0.0002210133,0.0003276596,0.0002397189,0.00005174456,0.0003644912,0.0004776956,0.0003955018,0.00008395965,0.001697095],"category_scores_gemma":[0.0001380541,0.0002974259,0.0002235412,0.0002802688,0.0001897695,0.0002626774,0.00007275774,0.0007967696,0.00004856172],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001250399,"about_ca_system_score_gemma":0.0001563506,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000002820516,"about_ca_topic_score_gemma":0.000005921826,"domain_scores_codex":[0.9982907,0.00002423811,0.000494052,0.0005075214,0.0002281494,0.0004553358],"domain_scores_gemma":[0.9986963,0.0002983583,0.0001821691,0.0004101084,0.0001104232,0.0003026687],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"not_applicable","study_design_scores_codex":[0.0001188426,0.0003299623,0.001655722,0.0006568902,0.0001762846,0.0007542473,0.0002246286,0.000213968,0.9673716,0.00008994761,0.02609102,0.002316842],"study_design_scores_gemma":[0.0022006,0.00003351786,0.001313961,0.00246474,0.0002454057,0.002833039,0.001727071,0.002628206,0.483647,0.000287695,0.5015303,0.001088357],"study_design_candidate":"bench_or_experimental","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9813599,0.0004332704,0.001050894,0.0009266284,0.00007786981,0.00009060886,0.001442341,0.0002394843,0.01437901],"genre_scores_gemma":[0.9921936,0.00009496086,0.001181383,0.00005097355,0.001316874,0.00007171701,0.0004274923,0.00009964444,0.00456329],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.4837246,"threshold_uncertainty_score":0.9999478,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02782713757304845,"score_gpt":0.2411417005772035,"score_spread":0.2133145630041551,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}