{"id":"W4391918700","doi":"10.1098/rstb.2022.0372","title":"Understanding the endo-lysosomal network in neurodegeneration","year":2024,"lang":"en","type":"article","venue":"Philosophical Transactions of the Royal Society B Biological Sciences","topic":"Lysosomal Storage Disorders Research","field":"Medicine","cited_by":6,"is_retracted":false,"has_abstract":false,"ca_institutions":"University of Toronto; University Health Network","funders":"National Institute on Aging; Medical Research Council; National Institutes of Health; ZonMw; Wellcome Trust; Lister Institute of Preventive Medicine; Consortium canadien en neurodégénérescence associée au vieillissement; Canadian Institutes of Health Research; Alzheimer Society","keywords":"Neurodegeneration; Neuroscience; Chemistry; Biology; Medicine; Disease; Pathology","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0008735462,0.0004367926,0.000688019,0.0008820763,0.0004000179,0.002200718,0.000831837,0.002113058,0.002539296],"category_scores_gemma":[0.0004979292,0.000211285,0.0003549977,0.0003837192,0.002027029,0.005485587,0.001678962,0.001490518,0.0007558297],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.001069586,"about_ca_system_score_gemma":0.0009610975,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001039214,"about_ca_topic_score_gemma":0.001211605,"domain_scores_codex":[0.999837,0.00003952341,0.00001302799,0.00003476167,0.00004039509,0.00003526284],"domain_scores_gemma":[0.9997737,0.00006102262,0.00004158508,0.00002561316,0.00004438406,0.00005372961],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"theoretical_or_conceptual","study_design_gemma":"not_applicable","study_design_scores_codex":[0.0004335449,0.0001250173,0.00721756,0.002979127,0.0002359943,0.00257235,0.001474301,0.01240456,0.1678647,0.5646806,0.01607087,0.2239414],"study_design_scores_gemma":[0.00003614553,0.0002328745,0.008010508,0.0007150038,0.00009779632,0.002293902,0.001657592,0.0132994,0.01802447,0.7437598,0.2117852,0.00008726018],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.1260389,0.7004044,0.06862366,0.05999173,0.003361729,0.0000513962,0.0004485318,0.0002490586,0.04083052],"genre_scores_gemma":[0.5890827,0.3692521,0.0224901,0.004919655,0.002510357,0.00007360154,0.0002725732,0.00004303425,0.01135597],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.002539296,"threshold_uncertainty_score":0.008494854,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.1778221236043904,"score_gpt":0.3312717970845602,"score_spread":0.1534496734801697,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}