{"id":"W4391921918","doi":"10.1101/2024.02.16.24302926","title":"Cost-effectiveness of romosozumab for severe postmenopausal osteoporosis at very high risk of fracture in Mexico.","year":2024,"lang":"en","type":"preprint","venue":"medRxiv","topic":"Cardiac, Anesthesia and Surgical Outcomes","field":"Medicine","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Toronto","funders":"Amgen","keywords":"Osteoporosis; Postmenopausal women; Postmenopausal osteoporosis; Medicine; Fracture (geology); Business; Internal medicine; Materials science; Bone mineral; Composite material","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.002106802,0.0004831729,0.0006847663,0.0004786382,0.0001837599,0.0008927891,0.0005996796,0.000741159,0.003284163],"category_scores_gemma":[0.004010034,0.0003211232,0.002240597,0.0003412824,0.0002316968,0.0004071064,0.0004315416,0.0005710214,0.00008664073],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.002635418,"about_ca_system_score_gemma":0.00168887,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.01732008,"about_ca_topic_score_gemma":0.009697393,"domain_scores_codex":[0.9994211,0.0003941396,0.00001835991,0.00005217098,0.00005062549,0.00006362553],"domain_scores_gemma":[0.9988966,0.0007074025,0.0002632663,0.00003285458,0.00004991285,0.00004993194],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"simulation_or_modeling","study_design_gemma":"observational","study_design_scores_codex":[0.04126908,0.001195524,0.1266883,0.003189008,0.01055203,0.001017158,0.0001569855,0.7031321,0.004070363,0.009808905,0.003895496,0.09502497],"study_design_scores_gemma":[0.0146531,0.01815206,0.1986597,0.002637824,0.02603396,0.001830678,0.0007180162,0.6968461,0.003765375,0.01572555,0.02077927,0.0001983358],"study_design_candidate":"observational","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9739553,0.01161266,0.005195932,0.002085457,0.00006885923,0.0003126445,0.002480796,0.00004818587,0.004240134],"genre_scores_gemma":[0.9959244,0.001894817,0.001099084,0.0001114851,0.00001423545,0.00008112558,0.0005640874,0.00000396312,0.0003068072],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.01732008,"threshold_uncertainty_score":0.03443855,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02113615631994331,"score_gpt":0.2989059338869485,"score_spread":0.2777697775670052,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}