{"id":"W4391929381","doi":"10.3389/fcimb.2024.1354636","title":"Identification of potential novel proteomic markers of Leishmania spp.-derived exosomes","year":2024,"lang":"en","type":"article","venue":"Frontiers in Cellular and Infection Microbiology","topic":"Extracellular vesicles in disease","field":"Biochemistry, Genetics and Molecular Biology","cited_by":12,"is_retracted":false,"has_abstract":true,"ca_institutions":"Northern Alberta Institute of Technology; McGill University; University of Alberta; McGill University Health Centre","funders":"Fonds de Recherche du Québec - Santé; Canadian Institutes of Health Research","keywords":"Microvesicles; Biology; Leishmania; Proteomics; Cell biology; ESCRT; Endosome; Trypanosoma brucei; Function (biology); Leishmania major; Quantitative proteomics; Computational biology; Exosome; Biogenesis; Genetics; Intracellular; Parasite hosting; Gene; microRNA","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001773781,0.0005007063,0.0002413722,0.001037543,0.0002225602,0.0005442996,0.0001772719,0.0004292559,0.0007856981],"category_scores_gemma":[0.0002815456,0.0001616993,0.0003598155,0.0004548051,0.0002043787,0.0003601392,0.0003747151,0.000276411,0.0003755279],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001872587,"about_ca_system_score_gemma":0.0002438696,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002254017,"about_ca_topic_score_gemma":0.0002734694,"domain_scores_codex":[0.9998733,0.00001609682,0.00001479092,0.00003648679,0.00002714231,0.00003214241],"domain_scores_gemma":[0.9998955,0.00001839344,0.00003020138,0.000006107689,0.00003176544,0.00001811916],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00009246362,0.00001699569,0.00237486,0.0001490654,0.00001960402,0.000231806,0.00003467095,0.00006082539,0.9936186,0.0001924578,0.00008435674,0.003124127],"study_design_scores_gemma":[0.00002260189,0.0002468523,0.06005028,0.00007021669,0.00012261,0.003974429,0.0002993123,0.00332526,0.9200511,0.0006941383,0.01111008,0.0000331009],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9802398,0.004783648,0.01111301,0.0002417197,0.0000742882,0.00006230045,0.001734166,0.0001335532,0.001617492],"genre_scores_gemma":[0.9716719,0.002846468,0.01976644,0.0002062998,0.00004948003,0.00008988655,0.002807835,0.00004538006,0.002516189],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001037543,"threshold_uncertainty_score":0.002628446,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.003926786625025417,"score_gpt":0.2074318756167753,"score_spread":0.2035050889917498,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}