{"id":"W4391931733","doi":"10.1038/s41592-024-02172-2","title":"Generation of complex bone marrow organoids from human induced pluripotent stem cells","year":2024,"lang":"en","type":"article","venue":"Nature Methods","topic":"Mesenchymal stem cell research","field":"Medicine","cited_by":129,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of British Columbia","funders":"National Institute of Diabetes and Digestive and Kidney Diseases; Hector Stiftung; Medizinische Universität Wien; Universität Wien; Bundesministerium für Bildung und Forschung; Ludwig-Maximilians-Universität München; Deutsche Forschungsgemeinschaft; Fondation Leducq; European Commission; Bundesministerium für Bildung, Wissenschaft und Forschung; Deutsches Zentrum für Infektionsforschung; Else Kröner-Fresenius-Stiftung; Leona M. and Harry B. Helmsley Charitable Trust; Österreichischen Akademie der Wissenschaften; European Federation of Pharmaceutical Industries and Associations; U.S. Department of Health and Human Services","keywords":"Organoid; Induced pluripotent stem cell; Stem cell; Cell biology; Bone marrow; Human bone; Biology; Human Induced Pluripotent Stem Cells; Computational biology; Embryonic stem cell; Immunology; Genetics; Gene; In vitro","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003133084,0.0003870861,0.0002576706,0.0003158299,0.0001517575,0.0003477799,0.0003308648,0.000326358,0.001899126],"category_scores_gemma":[0.0001914302,0.0002068498,0.0003483144,0.0002008323,0.0002088335,0.0001827642,0.0004159723,0.0005502108,0.000772186],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001779549,"about_ca_system_score_gemma":0.0002475881,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002531211,"about_ca_topic_score_gemma":0.0005519834,"domain_scores_codex":[0.9998794,0.0000160592,0.00001737135,0.00002929243,0.0000462475,0.00001159926],"domain_scores_gemma":[0.9998909,0.00002570105,0.00002319044,0.00002391045,0.0000129854,0.00002319809],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00006553818,0.00002204693,0.0003415739,0.0001160652,0.00001286793,0.0001414011,0.00005211518,0.001098653,0.991825,0.000720366,0.0002007468,0.005403573],"study_design_scores_gemma":[0.00004093659,0.0002396498,0.001628471,0.00003312845,0.00004161433,0.0004974343,0.00003844228,0.003412508,0.9709325,0.0003543843,0.02276837,0.00001246806],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"methods","genre_scores_codex":[0.7081394,0.00489914,0.2637745,0.0003297799,0.0003292593,0.001910049,0.009058242,0.001068113,0.01049155],"genre_scores_gemma":[0.8677127,0.002509714,0.1129822,0.000144274,0.00002672657,0.000855648,0.009196601,0.0001560458,0.006416094],"genre_candidate":"methods","genre_consensus":null,"teacher_disagreement_score":0.001899126,"threshold_uncertainty_score":0.006353199,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.1815181986164277,"score_gpt":0.456538529775567,"score_spread":0.2750203311591394,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}