{"id":"W4391931733","doi":"10.1038/s41592-024-02172-2","title":"Generation of complex bone marrow organoids from human induced pluripotent stem cells","year":2024,"lang":"en","type":"article","venue":"Nature Methods","topic":"Mesenchymal stem cell research","field":"Medicine","cited_by":129,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of British Columbia","funders":"National Institute of Diabetes and Digestive and Kidney Diseases; Hector Stiftung; Medizinische Universität Wien; Universität Wien; Bundesministerium für Bildung und Forschung; Ludwig-Maximilians-Universität München; Deutsche Forschungsgemeinschaft; Fondation Leducq; European Commission; Bundesministerium für Bildung, Wissenschaft und Forschung; Deutsches Zentrum für Infektionsforschung; Else Kröner-Fresenius-Stiftung; Leona M. and Harry B. Helmsley Charitable Trust; Österreichischen Akademie der Wissenschaften; European Federation of Pharmaceutical Industries and Associations; U.S. Department of Health and Human Services","keywords":"Organoid; Induced pluripotent stem cell; Stem cell; Cell biology; Bone marrow; Human bone; Biology; Human Induced Pluripotent Stem Cells; Computational biology; Embryonic stem cell; Immunology; Genetics; Gene; In vitro","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["insufficient_payload"],"consensus_categories":[],"category_scores_codex":[0.001621793,0.0002087415,0.0005196982,0.0002780005,0.00007210274,0.00005007006,0.0001648336,0.0005805185,0.001580777],"category_scores_gemma":[0.0001309437,0.0001647045,0.0001577641,0.0006055741,0.00005808148,0.00005978981,0.000111988,0.00136122,0.00005011704],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001730927,"about_ca_system_score_gemma":0.0001616053,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001396421,"about_ca_topic_score_gemma":0.00002024326,"domain_scores_codex":[0.9972508,0.0006950827,0.0004769926,0.0005003228,0.0007812504,0.0002955297],"domain_scores_gemma":[0.9985683,0.0003730158,0.00007792241,0.0005399416,0.0002434465,0.0001973855],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00003642038,0.00005922916,0.000118942,0.0002742195,0.0001100039,0.00009479697,0.0002205889,0.000001945823,0.9325033,0.0005942154,0.005368313,0.06061802],"study_design_scores_gemma":[0.0004996777,0.000228846,0.001615973,0.0001498398,0.0001087642,0.00001570952,0.0000774322,0.003726575,0.9680799,0.0002184335,0.02513638,0.0001424869],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.970255,0.009054734,0.01167743,0.001171332,0.001360745,0.0008156378,0.00004372532,0.0001500497,0.005471325],"genre_scores_gemma":[0.8666766,0.00003955956,0.127081,0.0002017546,0.0008701918,0.00001506176,0.0001081117,0.00005540883,0.00495238],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.1154036,"threshold_uncertainty_score":0.9993319,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.1815181986164277,"score_gpt":0.456538529775567,"score_spread":0.2750203311591394,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}