{"id":"W4391932941","doi":"10.1002/bit.28665","title":"An optimized polymeric delivery system for <i>piggyBac</i> transposition","year":2024,"lang":"en","type":"article","venue":"Biotechnology and Bioengineering","topic":"RNA Interference and Gene Delivery","field":"Biochemistry, Genetics and Molecular Biology","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Alberta","funders":"Canadian Institutes of Health Research; Natural Sciences and Engineering Research Council of Canada; Mitacs; Bill and Melinda Gates Foundation","keywords":"Transposase; Gene delivery; Green fluorescent protein; Transfection; Molecular biology; Transgene; Transduction (biophysics); Polyethylenimine; Biology; Cell biology; Plasmid; Viral vector; Transposition (logic); Gene; Transposable element; Chemistry; Biochemistry; Genome; Recombinant DNA","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002173298,0.0005883578,0.0002724688,0.0002945901,0.0001737995,0.0003392657,0.000294895,0.0005495104,0.0005367387],"category_scores_gemma":[0.0001622203,0.0001946212,0.0002486109,0.0002653593,0.0001500138,0.000287509,0.0001616586,0.0004321231,0.0005552079],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003679321,"about_ca_system_score_gemma":0.0003299139,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0005511367,"about_ca_topic_score_gemma":0.0007000797,"domain_scores_codex":[0.9998129,0.00003310713,0.00002409489,0.00004941678,0.00005140066,0.00002920129],"domain_scores_gemma":[0.9999232,0.00001095806,0.00003584591,0.000006198011,0.00001439142,0.000009288288],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00001277691,0.00001068665,0.00002037518,0.00004536509,0.000002922076,0.00003198384,0.0000063406,0.0001041573,0.9978862,0.00006619569,0.00002833082,0.001784577],"study_design_scores_gemma":[0.000008475258,0.0001516237,0.0003351099,0.000005171575,0.00001721506,0.0001809362,0.000004191629,0.0005490857,0.9931993,0.00001777928,0.005521658,0.000009443551],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.833656,0.006014697,0.1538407,0.000400689,0.0001836531,0.0006065689,0.0005642215,0.0009512838,0.00378223],"genre_scores_gemma":[0.8644325,0.004294019,0.1220809,0.0001756589,0.00006050246,0.0004002607,0.001091826,0.0002012529,0.007263051],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0005883578,"threshold_uncertainty_score":0.002669573,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.005084649173857771,"score_gpt":0.2136873528623832,"score_spread":0.2086027036885254,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}