{"id":"W4391943869","doi":"10.1038/s41598-024-53662-4","title":"Modified host defence peptide GF19 slows TNT-mediated spread of corneal herpes simplex virus serotype I infection","year":2024,"lang":"en","type":"article","venue":"Scientific Reports","topic":"Antimicrobial Peptides and Activities","field":"Immunology and Microbiology","cited_by":2,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Ottawa; Université de Montréal; Hôpital Maisonneuve-Rosemont","funders":"Fonds de Recherche du Québec - Santé; Karolinska Institutet; Natural Sciences and Engineering Research Council of Canada; Queen's University; Canada Research Chairs","keywords":"Cathelicidin; Immune system; Chemokine; Virology; Herpes simplex virus; Viral entry; Microbiology; Biology; Virus; Innate immune system; Immunology; Viral replication","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00007447635,0.0002389608,0.0001637109,0.0001173201,0.00006724027,0.0001087652,0.0001117489,0.0001883065,0.0007852778],"category_scores_gemma":[0.0001271929,0.00004963642,0.0001706199,0.000055729,0.0001262129,0.00012282,0.0001261365,0.0002720978,0.0001164105],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001225457,"about_ca_system_score_gemma":0.0001096526,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003524708,"about_ca_topic_score_gemma":0.0004121953,"domain_scores_codex":[0.9999521,0.0000070317,0.000003565735,0.0000091896,0.00001098807,0.0000171309],"domain_scores_gemma":[0.9999536,0.000009618792,0.00001056396,0.000003593769,0.000006287005,0.00001618666],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001411922,0.00003103382,0.00006307157,0.00002396188,0.000002967186,0.00003007058,0.000004882424,0.00005196915,0.9982176,0.00001442921,0.0000218965,0.001396757],"study_design_scores_gemma":[0.00002529901,0.001444497,0.001760824,0.000006451774,0.00001003637,0.0001448428,0.000008041078,0.0004273832,0.9951853,0.00001214255,0.0009716451,0.000003505083],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9982857,0.0005918023,0.0004511427,0.00002502924,0.00002387615,0.00002197039,0.00007153788,0.00001629778,0.0005125739],"genre_scores_gemma":[0.9968708,0.0005022321,0.001462978,0.00004193019,0.00001064594,0.0000201767,0.0001662171,0.00001040154,0.0009146094],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0007852778,"threshold_uncertainty_score":0.002627075,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01718606047604304,"score_gpt":0.2464308449705186,"score_spread":0.2292447844944756,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}