{"id":"W4391946949","doi":"10.3390/jcm13041160","title":"TGF-β1, pSmad-2/3, Smad-7, and β-Catenin Are Augmented in the Pulmonary Arteries from Patients with Idiopathic Pulmonary Fibrosis (IPF): Role in Driving Endothelial-to-Mesenchymal Transition (EndMT)","year":2024,"lang":"en","type":"article","venue":"Journal of Clinical Medicine","topic":"Interstitial Lung Diseases and Idiopathic Pulmonary Fibrosis","field":"Medicine","cited_by":16,"is_retracted":false,"has_abstract":true,"ca_institutions":"St. Paul's Hospital; University of British Columbia","funders":"Lung Foundation Australia","keywords":"Medicine; Idiopathic pulmonary fibrosis; SMAD; Intimal hyperplasia; Transforming growth factor; Pulmonary artery; Pathology; Internal medicine; Fibrosis; Pulmonary fibrosis; Vimentin; Lung; Immunohistochemistry","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001908743,0.0002109066,0.000185106,0.0006555726,0.0002212094,0.0002639239,0.00008749666,0.0002184192,0.001446523],"category_scores_gemma":[0.0003636412,0.0001506734,0.0001441973,0.0002052236,0.0002299529,0.0001611506,0.0001815197,0.0002306338,0.0001460963],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001139945,"about_ca_system_score_gemma":0.00007111828,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003247187,"about_ca_topic_score_gemma":0.0005171534,"domain_scores_codex":[0.999876,0.00001509662,0.00001730895,0.00003446615,0.00003714853,0.00001991999],"domain_scores_gemma":[0.9996903,0.00005345304,0.0001491217,0.00001612323,0.0000341486,0.00005691002],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.001059232,0.00008700552,0.7083437,0.00009616986,0.00005856083,0.002219497,0.0004318357,0.00008442971,0.2798176,0.0000584484,0.00007913908,0.007664445],"study_design_scores_gemma":[0.000007129093,0.0001825977,0.9827493,0.000005223741,0.00003972184,0.004459377,0.0002055459,0.000227398,0.01188323,0.00002902439,0.0002087486,0.000002644248],"study_design_candidate":"bench_or_experimental","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.99958,0.0001212609,0.0001426958,0.000005556714,0.000001033339,0.000002045636,0.00003152531,0.00000458139,0.0001112762],"genre_scores_gemma":[0.9996294,0.00004638013,0.0001655998,0.000003831539,0.000002486256,0.000003018302,0.00005992392,0.000001120402,0.00008818231],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001446523,"threshold_uncertainty_score":0.004839063,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01539367901826649,"score_gpt":0.2980003386079444,"score_spread":0.2826066595896779,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}