{"id":"W4391951899","doi":"10.1021/acschembio.3c00773","title":"Antibacterial Marinopyrroles and Pseudilins Act as Protonophores","year":2024,"lang":"en","type":"article","venue":"ACS Chemical Biology","topic":"RNA and protein synthesis mechanisms","field":"Biochemistry, Genetics and Molecular Biology","cited_by":10,"is_retracted":false,"has_abstract":true,"ca_institutions":"Simon Fraser University","funders":"National Institute of General Medical Sciences; Natural Sciences and Engineering Research Council of Canada; Deutsche Forschungsgemeinschaft; Canadian Network for Research and Innovation in Machining Technology, Natural Sciences and Engineering Research Council of Canada; Deutsches Zentrum für Infektionsforschung","keywords":"Protonophore; Peptidoglycan; Antibacterial activity; Bacteria; Biology; Biophysics; Biochemistry; Teichoic acid; Membrane; Cytoplasm; Chemiosmosis; Bacterial cell structure; Mechanism of action; Chemistry; Cell membrane; Staphylococcus aureus; Cell wall; In vitro; ATP synthase","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001194402,0.0001661655,0.0001612589,0.00002955223,0.00003595879,0.00004133749,0.0001585173,0.0003430803,0.00007809551],"category_scores_gemma":[0.0001133425,0.0001328897,0.00005971931,0.00004523968,0.0001500553,0.000003329379,0.0001977086,0.00009310271,0.00005267764],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000005875585,"about_ca_system_score_gemma":0.00005137391,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00001335259,"about_ca_topic_score_gemma":0.000001318133,"domain_scores_codex":[0.9990357,0.00004833241,0.0001609685,0.0004669483,0.00004234286,0.0002457767],"domain_scores_gemma":[0.9996349,0.00003110266,0.00002520783,0.0002093209,0.00001988688,0.00007953591],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001222438,0.00001640889,0.0003760287,0.00002861365,0.00004878318,0.00000574321,0.00001277104,1.970922e-8,0.9734946,0.001580905,0.0002887207,0.02402514],"study_design_scores_gemma":[0.0001567505,0.0002143451,0.00007440231,0.00001523181,0.00001292424,0.00005622179,0.000006156998,0.000002959419,0.9102216,0.002831424,0.08624747,0.0001604696],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9962148,0.001516812,0.00007758784,0.0004020975,0.0002335971,0.0002633595,0.00002271068,0.00003956847,0.001229448],"genre_scores_gemma":[0.9975957,0.0005824452,0.0005842947,0.0002385191,0.0005181616,0.0000776193,0.0001316841,0.00002187017,0.0002497082],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.08595875,"threshold_uncertainty_score":0.5419085,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.007521863293628957,"score_gpt":0.2567451482151132,"score_spread":0.2492232849214843,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}