{"id":"W4391951899","doi":"10.1021/acschembio.3c00773","title":"Antibacterial Marinopyrroles and Pseudilins Act as Protonophores","year":2024,"lang":"en","type":"article","venue":"ACS Chemical Biology","topic":"RNA and protein synthesis mechanisms","field":"Biochemistry, Genetics and Molecular Biology","cited_by":10,"is_retracted":false,"has_abstract":true,"ca_institutions":"Simon Fraser University","funders":"National Institute of General Medical Sciences; Natural Sciences and Engineering Research Council of Canada; Deutsche Forschungsgemeinschaft; Canadian Network for Research and Innovation in Machining Technology, Natural Sciences and Engineering Research Council of Canada; Deutsches Zentrum für Infektionsforschung","keywords":"Protonophore; Peptidoglycan; Antibacterial activity; Bacteria; Biology; Biophysics; Biochemistry; Teichoic acid; Membrane; Cytoplasm; Chemiosmosis; Bacterial cell structure; Mechanism of action; Chemistry; Cell membrane; Staphylococcus aureus; Cell wall; In vitro; ATP synthase","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001139359,0.0002803195,0.0001163456,0.000109457,0.0001042856,0.0002342258,0.0001886053,0.0003380286,0.0008173898],"category_scores_gemma":[0.0001076742,0.0001316713,0.0002072435,0.00005728556,0.0002392149,0.0003322642,0.0002583318,0.0002410224,0.0002520129],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001879707,"about_ca_system_score_gemma":0.0001063819,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002108483,"about_ca_topic_score_gemma":0.000299481,"domain_scores_codex":[0.9998984,0.00002355882,0.000005142764,0.00002362245,0.00003047912,0.00001873404],"domain_scores_gemma":[0.9998971,0.00002423716,0.00003713369,0.00000920131,0.00001400369,0.00001828449],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00006186961,0.000008723554,0.0001603742,0.00004063476,0.000003355304,0.00006083628,0.000009991709,0.0001006516,0.9979659,0.0003009003,0.00001543703,0.001271333],"study_design_scores_gemma":[0.00001863602,0.0004849784,0.003676486,0.000004467341,0.000007628269,0.0003366814,0.00002982802,0.000809629,0.9917514,0.0001539834,0.002720455,0.00000572846],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9833951,0.003310559,0.007064977,0.0001732535,0.00002664733,0.00004500224,0.000127153,0.0000746096,0.005782666],"genre_scores_gemma":[0.994718,0.0007723662,0.002740877,0.00006824524,0.000006893354,0.00001746204,0.00005324914,0.000006330398,0.001616542],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0008173898,"threshold_uncertainty_score":0.002734423,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.007521863293628957,"score_gpt":0.2567451482151132,"score_spread":0.2492232849214843,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}