{"id":"W4391957127","doi":"10.2139/ssrn.4729016","title":"Epigenome-Wide Analysis Identifies CRTAP as a Pollution-Sensitive Locus in Fibrotic Interstitial Lung Disease: A Retrospective Cohort Study","year":2024,"lang":"en","type":"preprint","venue":"SSRN Electronic Journal","topic":"Interstitial Lung Diseases and Idiopathic Pulmonary Fibrosis","field":"Medicine","cited_by":0,"is_retracted":false,"has_abstract":false,"ca_institutions":"University of Calgary; University of British Columbia","funders":"","keywords":"Epigenome; Interstitial lung disease; Locus (genetics); Cohort; Retrospective cohort study; Disease; Medicine; Pollution; Environmental health; Pathology; Lung; Internal medicine; Biology; Genetics; Ecology; Gene; DNA methylation","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0008649069,0.0005595211,0.0006172451,0.0006087361,0.0007307634,0.001207219,0.00063778,0.001053792,0.002135946],"category_scores_gemma":[0.001649977,0.0005673119,0.001173388,0.001405469,0.0003886083,0.0004570434,0.0008556776,0.000975166,0.0003913342],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002112014,"about_ca_system_score_gemma":0.0003037468,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.005289427,"about_ca_topic_score_gemma":0.004670041,"domain_scores_codex":[0.999213,0.0001654073,0.00004635696,0.0004115494,0.0000707334,0.00009290977],"domain_scores_gemma":[0.9991085,0.0001594028,0.0002120557,0.0002790548,0.0001098646,0.0001312064],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.001025604,0.00005903111,0.9894493,0.00003513712,0.001068344,0.0004523981,0.0002239497,0.0001245422,0.004889725,0.0001299552,0.0005760032,0.001966127],"study_design_scores_gemma":[0.0000337589,0.0001129724,0.997852,0.000008741727,0.0003841069,0.0004549472,0.0001633305,0.0002212459,0.0001937891,0.0001097529,0.0004548355,0.00001058968],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9964798,0.0004523034,0.0005790712,0.00008291312,0.00001926206,0.00001005006,0.00206278,0.00001336963,0.0003004597],"genre_scores_gemma":[0.9982961,0.0001577714,0.0002878226,0.00005780752,0.00001784178,0.00001152879,0.0008130203,0.00001304013,0.0003451693],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.005289427,"threshold_uncertainty_score":0.0105173,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.005693827854537864,"score_gpt":0.2745571932983694,"score_spread":0.2688633654438315,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}