{"id":"W4391957956","doi":"10.1124/dmd.123.001611","title":"Identification and Biosynthesis of an N-Glucuronide Metabolite of Camonsertib","year":2024,"lang":"en","type":"article","venue":"Drug Metabolism and Disposition","topic":"Carbohydrate Chemistry and Synthesis","field":"Chemistry","cited_by":1,"is_retracted":false,"has_abstract":false,"ca_institutions":"Telesta Therapeutics (Canada)","funders":"","keywords":"Metabolite; Biosynthesis; Identification (biology); Glucuronide; Computational biology; Chemistry; Biochemistry; Biology; Botany; Gene","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001906622,0.0008915284,0.0003191089,0.0006349388,0.0003994605,0.00068274,0.0003389015,0.0006133991,0.001354598],"category_scores_gemma":[0.000414619,0.0002636814,0.0005723744,0.0004249887,0.0003021093,0.0004298212,0.0003292004,0.0007361959,0.0006589467],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.001165689,"about_ca_system_score_gemma":0.001314973,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00339163,"about_ca_topic_score_gemma":0.00430222,"domain_scores_codex":[0.9997974,0.00004170144,0.0000128445,0.00004433532,0.00004750153,0.00005617282],"domain_scores_gemma":[0.9997961,0.00002462013,0.00004592283,0.00002457326,0.00004140552,0.00006752871],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0009118664,0.00009116237,0.002259594,0.00005573069,0.00004159746,0.00199329,0.0000873123,0.0008003236,0.9785615,0.0008466841,0.0002473635,0.0141035],"study_design_scores_gemma":[0.00004702877,0.0006218781,0.008676371,0.00001576335,0.00005778502,0.002010401,0.0001011105,0.001895875,0.9780491,0.0003158093,0.008186827,0.00002200433],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9762191,0.00313511,0.01094573,0.0005543113,0.0001526067,0.0001570538,0.002408726,0.0001178547,0.006309601],"genre_scores_gemma":[0.9726834,0.001449574,0.01423004,0.0002202755,0.00004786835,0.00005842924,0.004881338,0.00005494397,0.006374208],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.00339163,"threshold_uncertainty_score":0.00845772,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.005142047573756402,"score_gpt":0.2202364297199746,"score_spread":0.2150943821462181,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}