{"id":"W4391963812","doi":"10.1128/spectrum.04095-23","title":"A chemical screen identifies structurally diverse metal chelators with activity against the fungal pathogen <i>Candida albicans</i>","year":2024,"lang":"en","type":"article","venue":"Microbiology Spectrum","topic":"Antifungal resistance and susceptibility","field":"Medicine","cited_by":10,"is_retracted":false,"has_abstract":true,"ca_institutions":"Brock University; University of Toronto","funders":"National Center for Advancing Translational Sciences; Canadian Institutes of Health Research; National Institutes of Health; National Institute of General Medical Sciences; Canadian Institute for Advanced Research","keywords":"Candida albicans; Corpus albicans; Microbiology; Aspergillus fumigatus; Xanthone; Biology; Candida glabrata; Pathogen; Antifungal drug; Efflux; Echinocandins; Natural product; Amphotericin B; Chemistry; Biochemistry; Antifungal; Caspofungin","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001718774,0.0005036279,0.0004059763,0.0007701387,0.0001960871,0.0002288104,0.0003593413,0.0002971182,0.002059169],"category_scores_gemma":[0.0001619497,0.0001294365,0.0003622521,0.0005160486,0.0001654895,0.0001502643,0.0002281947,0.0002670232,0.0005274958],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002395267,"about_ca_system_score_gemma":0.0003383991,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000911567,"about_ca_topic_score_gemma":0.002737283,"domain_scores_codex":[0.9998633,0.00002150374,0.00001227328,0.00003234766,0.00004023191,0.00003034568],"domain_scores_gemma":[0.999925,0.00001469585,0.0000160233,0.000005638936,0.00001681908,0.00002183813],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0006303918,0.0003601035,0.001426084,0.0004482082,0.00005573843,0.000233584,0.00002521625,0.000591301,0.9762272,0.0001546777,0.0008073995,0.01904008],"study_design_scores_gemma":[0.0006544139,0.01192453,0.02048256,0.0001176872,0.0003315975,0.001558743,0.00007358794,0.002148175,0.9461217,0.0001370492,0.01640193,0.00004808209],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9680815,0.01294324,0.002783207,0.0005179236,0.00007977061,0.0005110621,0.004190272,0.0003942442,0.01049878],"genre_scores_gemma":[0.9807025,0.005019931,0.005002318,0.0004854853,0.00002978804,0.0001127779,0.004327949,0.00002021178,0.004299055],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002059169,"threshold_uncertainty_score":0.006888568,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.007980736860561048,"score_gpt":0.2344704544895997,"score_spread":0.2264897176290387,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}