{"id":"W4391965663","doi":"10.3390/biomedicines12020461","title":"L-DOS47 Elevates Pancreatic Cancer Tumor pH and Enhances Response to Immunotherapy","year":2024,"lang":"en","type":"article","venue":"Biomedicines","topic":"Cancer, Hypoxia, and Metabolism","field":"Biochemistry, Genetics and Molecular Biology","cited_by":11,"is_retracted":false,"has_abstract":true,"ca_institutions":"Helix Biopharma (Canada)","funders":"National Cancer Institute; Associazione Italiana per la Ricerca sul Cancro; Moffitt Cancer Center","keywords":"Pancreatic cancer; Immunotherapy; Chemistry; Cancer research; Immunoconjugate; Cancer immunotherapy; Cancer; Medicine; Antibody; Immunology; Internal medicine","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002314111,0.0001595038,0.0001918363,0.000108985,0.00005227559,0.00003780361,0.0001022551,0.00005712025,0.00006217281],"category_scores_gemma":[0.00007028304,0.0001192111,0.0000449603,0.000209914,0.0001167671,0.000004362987,0.00003758316,0.00004473139,0.00001250671],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00001133004,"about_ca_system_score_gemma":0.0001203356,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001712631,"about_ca_topic_score_gemma":0.00004483318,"domain_scores_codex":[0.9991189,0.0000422251,0.0001607807,0.0003468454,0.0001151369,0.0002161642],"domain_scores_gemma":[0.9995915,0.00003537515,0.00002537445,0.0001991993,0.00004722605,0.0001013333],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"not_applicable","study_design_scores_codex":[0.0004939513,0.00001074164,0.0001822169,0.00005154783,0.00007504971,0.000003133721,0.0002423608,3.808468e-7,0.9545081,0.00001117503,0.01534552,0.02907586],"study_design_scores_gemma":[0.0003178859,0.0002188559,0.004203923,0.0001094442,0.00002968545,0.00002011186,0.000107739,0.000007959925,0.2747462,0.00002677857,0.7200746,0.0001367681],"study_design_candidate":"bench_or_experimental","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.8472142,0.1487782,0.0001339567,0.00176102,0.001800139,0.0001705196,0.00003951943,0.00003052137,0.00007194536],"genre_scores_gemma":[0.9683452,0.01974841,0.0002897021,0.001604911,0.004072381,0.0001497919,0.00002614013,0.00003913165,0.005724319],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.7047291,"threshold_uncertainty_score":0.4861287,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.007651049618509051,"score_gpt":0.2840801365570705,"score_spread":0.2764290869385615,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}