{"id":"W4391965663","doi":"10.3390/biomedicines12020461","title":"L-DOS47 Elevates Pancreatic Cancer Tumor pH and Enhances Response to Immunotherapy","year":2024,"lang":"en","type":"article","venue":"Biomedicines","topic":"Cancer, Hypoxia, and Metabolism","field":"Biochemistry, Genetics and Molecular Biology","cited_by":11,"is_retracted":false,"has_abstract":true,"ca_institutions":"Helix Biopharma (Canada)","funders":"National Cancer Institute; Associazione Italiana per la Ricerca sul Cancro; Moffitt Cancer Center","keywords":"Pancreatic cancer; Immunotherapy; Chemistry; Cancer research; Immunoconjugate; Cancer immunotherapy; Cancer; Medicine; Antibody; Immunology; Internal medicine","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001124316,0.0003164795,0.0004430305,0.0002046612,0.00007781499,0.0002496587,0.0001245067,0.0002446885,0.000979075],"category_scores_gemma":[0.0001112345,0.00009747083,0.0002201527,0.0001345213,0.0001757813,0.0002132795,0.000181125,0.0006357784,0.0001739247],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001737453,"about_ca_system_score_gemma":0.0001576514,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002131898,"about_ca_topic_score_gemma":0.0002987389,"domain_scores_codex":[0.9999162,0.00001513993,0.000006014046,0.00001120215,0.00002121053,0.00003033444],"domain_scores_gemma":[0.9999186,0.00001657752,0.00002392777,0.000009494102,0.00000537158,0.00002606856],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.001074366,0.0004353322,0.0003168357,0.00005839692,0.00001323928,0.00003749287,0.00001915708,0.0002883312,0.9917248,0.00004920534,0.0001144254,0.005868268],"study_design_scores_gemma":[0.0001599716,0.006539603,0.004268543,0.000006824597,0.00003111588,0.0001766054,0.00003041684,0.001464664,0.9853346,0.00004312093,0.001938128,0.000006422633],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9976116,0.000858616,0.0004617776,0.00007426753,0.00002671946,0.00002673078,0.00009330207,0.00007230054,0.0007746622],"genre_scores_gemma":[0.9975931,0.0006096206,0.0005413893,0.00005558952,0.00001936988,0.00003504042,0.0002083839,0.00001537043,0.0009219713],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.000979075,"threshold_uncertainty_score":0.003275275,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.007651049618509051,"score_gpt":0.2840801365570705,"score_spread":0.2764290869385615,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}