{"id":"W4391967894","doi":"10.3389/fimmu.2024.1282754","title":"Immunological signatures unveiled by integrative systems vaccinology characterization of dengue vaccination trials and natural infection","year":2024,"lang":"en","type":"article","venue":"Frontiers in Immunology","topic":"Mosquito-borne diseases and control","field":"Medicine","cited_by":5,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Toronto; Discovery Centre; University Health Network","funders":"","keywords":"Dengue fever; Dengue virus; Vaccination; Dengue vaccine; Immune system; Immunology; Biology; Virology; Computational biology; Medicine","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001844972,0.0003984354,0.0006453924,0.0008725809,0.0002140944,0.0008395143,0.0001976937,0.0002310764,0.000812119],"category_scores_gemma":[0.001688373,0.000100118,0.0007307425,0.0007884075,0.0003768216,0.000335961,0.000480218,0.0003440826,0.0001483047],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003820983,"about_ca_system_score_gemma":0.0004926374,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002519793,"about_ca_topic_score_gemma":0.000379997,"domain_scores_codex":[0.9990199,0.0003418057,0.00009081997,0.000247495,0.0001917453,0.0001082188],"domain_scores_gemma":[0.9989355,0.0004241988,0.0003352418,0.0001129681,0.0001332332,0.00005880351],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"observational","study_design_scores_codex":[0.003352332,0.0004762507,0.4435854,0.001491232,0.001158701,0.0001926066,0.0003251868,0.008389357,0.448677,0.0008107825,0.001257448,0.09028379],"study_design_scores_gemma":[0.0000752181,0.002577807,0.8676696,0.0001205344,0.0007980834,0.0006303426,0.0003840943,0.02468617,0.09393279,0.002322748,0.006749167,0.00005344598],"study_design_candidate":"observational","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9859552,0.002052619,0.00768264,0.0001182404,0.0000308419,0.0001002313,0.003121847,0.00006164591,0.0008768304],"genre_scores_gemma":[0.9877284,0.0004358161,0.006372349,0.000106482,0.00003020124,0.0001173986,0.004986491,0.00001731503,0.0002055383],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001844972,"threshold_uncertainty_score":0.00975728,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.007412031797009846,"score_gpt":0.2672586453079581,"score_spread":0.2598466135109483,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}