{"id":"W4391971389","doi":"10.1093/nar/gkae103","title":"The SMC5/6 complex: folding chromosomes back into shape when genomes take a break","year":2024,"lang":"en","type":"review","venue":"Nucleic Acids Research","topic":"Genomics and Chromatin Dynamics","field":"Biochemistry, Genetics and Molecular Biology","cited_by":21,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Ottawa","funders":"Canadian Institutes of Health Research","keywords":"Chromatin; Biology; Interphase; Cohesin; Cell biology; Folding (DSP implementation); Chromosome segregation; Context (archaeology); Genome; DNA; Computational biology; Genetics; Chromosome; Gene","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0004909872,0.0008383316,0.0008050769,0.002007107,0.0002709484,0.0008559786,0.0008416753,0.001071227,0.00266488],"category_scores_gemma":[0.0005639252,0.0002883672,0.000324606,0.001609196,0.0004863442,0.0013516,0.0006925612,0.001524136,0.002876842],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0007379463,"about_ca_system_score_gemma":0.001200416,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0009385943,"about_ca_topic_score_gemma":0.001592982,"domain_scores_codex":[0.999878,0.00001599286,0.0000159919,0.00002405999,0.00004937605,0.00001653551],"domain_scores_gemma":[0.9998242,0.00006393822,0.00002423052,0.000005568285,0.00005422011,0.00002781834],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.00006704739,0.00003214359,0.0001283146,0.01057009,0.00005923619,0.0001706293,0.00005706639,0.0003258841,0.002225515,0.005826498,0.03854389,0.9419937],"study_design_scores_gemma":[0.000006620005,0.00003759986,0.0003179395,0.001128376,0.00002955674,0.0005723602,0.00002345648,0.00003788099,0.000328621,0.001072704,0.9964365,0.000008471048],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.000128484,0.9972785,0.0001837476,0.0003823051,0.0003892085,0.000004754002,0.00002048126,0.00001155081,0.001600969],"genre_scores_gemma":[0.0004974349,0.9981229,0.0001814151,0.000203067,0.0001448478,0.000004987111,0.00003429274,0.000001930782,0.0008091123],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.00266488,"threshold_uncertainty_score":0.008914948,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.07909347652879223,"score_gpt":0.3769123183045527,"score_spread":0.2978188417757605,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}