{"id":"W4391972647","doi":"10.2460/ajvr.23.11.0267","title":"Low levels of microRNA-21 in neutrophil-derived exosomes may contribute to airway smooth muscle hyperproliferation in horses with severe asthma","year":2024,"lang":"en","type":"article","venue":"American Journal of Veterinary Research","topic":"Extracellular vesicles in disease","field":"Biochemistry, Genetics and Molecular Biology","cited_by":4,"is_retracted":false,"has_abstract":true,"ca_institutions":"Université de Montréal","funders":"Canadian Institutes of Health Research","keywords":"Microvesicles; microRNA; Immunology; Inflammation; Lipopolysaccharide; Biology; Exosome; Cell growth; Asthma; Transfection; Medicine; Cell biology; Cancer research; Cell culture; Gene","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002799261,0.0002698898,0.0003266104,0.0003643444,0.0002838214,0.0004597376,0.0001119775,0.0005198895,0.001274683],"category_scores_gemma":[0.0007332395,0.0001825143,0.0002084225,0.0001369104,0.000408921,0.0002536729,0.0002627191,0.0002942504,0.0001894539],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001717981,"about_ca_system_score_gemma":0.0001090733,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001784385,"about_ca_topic_score_gemma":0.0002413437,"domain_scores_codex":[0.9997577,0.00006205137,0.00003657499,0.00005450012,0.00005353174,0.0000355892],"domain_scores_gemma":[0.9996766,0.00006425972,0.0001765235,0.00001444505,0.00003384667,0.00003435519],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00225194,0.0001764896,0.1490997,0.0003394478,0.00007518216,0.001814059,0.0003921351,0.0001702741,0.8361573,0.0001335627,0.0001853283,0.009204561],"study_design_scores_gemma":[0.00004145472,0.002106488,0.8485962,0.00008215953,0.0002020929,0.006812909,0.0008615757,0.001967388,0.1364766,0.0002312675,0.002598588,0.00002310068],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9982907,0.0009257736,0.0004629106,0.00004021298,0.00001053208,0.00001388293,0.00005701307,0.000007577791,0.0001913097],"genre_scores_gemma":[0.9988821,0.0002061538,0.0004824313,0.00002667243,0.000008546152,0.00002090207,0.00007372419,0.000003390242,0.0002959807],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001274683,"threshold_uncertainty_score":0.004264235,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03027932792001975,"score_gpt":0.3376644888146581,"score_spread":0.3073851608946384,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}