{"id":"W4391986310","doi":"10.2196/56726","title":"Linking Dementia Pathology and Alteration in Brain Activation to Complex Daily Functional Decline During the Preclinical Dementia Stages: Protocol for a Prospective Observational Cohort Study","year":2024,"lang":"en","type":"article","venue":"JMIR Research Protocols","topic":"Dementia and Cognitive Impairment Research","field":"Medicine","cited_by":1,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"National Institute on Aging","keywords":"Dementia; Observational study; Medicine; Cohort study; Preprint; Gerontology; Prospective cohort study; Cohort; Neuroscience; Psychology; Pathology; Disease; World Wide Web","routes":{"ca_aff":false,"ca_fund":false,"ca_venue":true,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.01787284,0.003918014,0.003982758,0.001971492,0.004113567,0.001816992,0.002371316,0.003682973,0.01477457],"category_scores_gemma":[0.01506669,0.002061887,0.003862001,0.002208831,0.001305115,0.00175533,0.002040914,0.003139077,0.004092013],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.003476856,"about_ca_system_score_gemma":0.0119052,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.007851646,"about_ca_topic_score_gemma":0.0107367,"domain_scores_codex":[0.993486,0.002767633,0.001200035,0.001049406,0.0007648187,0.0007320654],"domain_scores_gemma":[0.9917208,0.00105954,0.00114848,0.001497633,0.003592706,0.0009808532],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"observational","study_design_scores_codex":[0.6092872,0.06395667,0.107248,0.01859581,0.006175613,0.002486304,0.003587804,0.009867317,0.01239447,0.007088635,0.06779812,0.09151408],"study_design_scores_gemma":[0.3568702,0.1239314,0.3613302,0.005452628,0.003658809,0.000780621,0.001872653,0.009380776,0.004766226,0.008945814,0.1220571,0.0009535552],"study_design_candidate":"observational","study_design_consensus":null,"genre_codex":"protocol","genre_gemma":"protocol","genre_scores_codex":[0.01787171,0.0003642778,0.004193543,0.0001962167,0.0002873858,0.9701748,0.005752189,0.0001108485,0.001048971],"genre_scores_gemma":[0.007828167,0.00008290647,0.002689357,0.0001056577,0.00002955605,0.9878306,0.0011337,0.000004594808,0.0002954539],"genre_candidate":"protocol","genre_consensus":"protocol","teacher_disagreement_score":0.01787284,"threshold_uncertainty_score":0.09452176,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.3406607400231168,"score_gpt":0.5763727289656243,"score_spread":0.2357119889425075,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}