{"id":"W4391990718","doi":"10.1055/s-0044-1779891","title":"Multicenter Prospective Validation of a DNA Methylation-Based Predictor of Meningioma Recurrence Risk and Molecular Classification","year":2024,"lang":"en","type":"article","venue":"Journal of Neurological Surgery Part B Skull Base","topic":"Meningioma and schwannoma management","field":"Medicine","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of British Columbia; University of Toronto","funders":"","keywords":"DNA methylation; Meningioma; Methylation; Oncology; Medicine; Internal medicine; DNA; Computer science; Biology; Radiology; Genetics; Gene","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.003946916,0.0005246524,0.0003376817,0.0008366698,0.0005716444,0.0007105654,0.0006743704,0.0005434598,0.000971691],"category_scores_gemma":[0.005513553,0.0003191668,0.0003013306,0.0007592501,0.0004231008,0.0003828249,0.000829977,0.0006557976,0.0006174054],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0005281163,"about_ca_system_score_gemma":0.0006929824,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.003092144,"about_ca_topic_score_gemma":0.004082219,"domain_scores_codex":[0.998567,0.0005003798,0.0001479894,0.0003833795,0.000260117,0.0001411577],"domain_scores_gemma":[0.9961827,0.000531277,0.001257426,0.0007597876,0.000837671,0.0004311509],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.000829304,0.0001471816,0.9910811,0.00001371459,0.00009288065,0.00004585822,0.00009641311,0.0001291907,0.004003485,0.00002661994,0.000330377,0.003204031],"study_design_scores_gemma":[0.00008567942,0.0008938804,0.9945683,0.000008607529,0.00008516254,0.0003228679,0.00008621236,0.0005017637,0.002622396,0.00003679818,0.0007803556,0.000007968455],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9958152,0.000131559,0.0009575788,0.00006872266,0.00001385167,0.000118595,0.002466719,0.00002245323,0.00040529],"genre_scores_gemma":[0.9939216,0.00005229951,0.001736528,0.00006140705,0.00002572067,0.0001513934,0.003730141,0.00001575672,0.0003052732],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.003946916,"threshold_uncertainty_score":0.02087355,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0402592105397063,"score_gpt":0.2807394518074491,"score_spread":0.2404802412677428,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}