{"id":"W4392001925","doi":"10.1002/adbi.202300117","title":"ILKAP Promotes the Metastasis of Hepatocellular Carcinoma Cells by Inhibiting β‐Catenin Degradation and Enhancing the WNT Signaling Pathway","year":2024,"lang":"en","type":"article","venue":"Advanced Biology","topic":"Wnt/β-catenin signaling in development and cancer","field":"Biochemistry, Genetics and Molecular Biology","cited_by":2,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Alberta","funders":"Wuhan Science and Technology Project; National Key Research and Development Program of China; Hubei University; Hubei University of Technology; National Natural Science Foundation of China","keywords":"Wnt signaling pathway; Hepatocellular carcinoma; Metastasis; Cancer research; Catenin; Degradation (telecommunications); Signal transduction; Chemistry; Beta-catenin; Cell biology; Internal medicine; Medicine; Biology; Cancer; Computer science; Telecommunications","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0004837102,0.0001725109,0.0001623892,0.00003017166,0.0001437711,0.00002681827,0.0001718804,0.0001074773,0.00001001071],"category_scores_gemma":[0.00005324598,0.0001013098,0.00006843804,0.0001347848,0.0001914386,0.000007908356,0.000113112,0.0001255048,0.000002307671],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000013116,"about_ca_system_score_gemma":0.00007376548,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00003150605,"about_ca_topic_score_gemma":0.00001031601,"domain_scores_codex":[0.9988915,0.0001182015,0.0003067237,0.0003652559,0.00007737856,0.0002409488],"domain_scores_gemma":[0.9995615,0.00009116976,0.0001107957,0.0001380578,0.00006907817,0.00002940515],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00001946405,0.00001498393,0.0004739837,0.00003882994,0.00005073905,0.000001361618,0.0001683212,0.00001385815,0.9868034,0.00017657,0.0001160087,0.01212252],"study_design_scores_gemma":[0.0002376073,0.0001244339,0.00001470102,0.00003935716,0.00003153651,0.000008685345,0.0002788495,0.0001704213,0.991394,0.0003140305,0.007243955,0.0001423915],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9757046,0.01859632,0.004941435,0.0002386596,0.0001878865,0.0002396954,0.00002743095,0.00001746165,0.00004655157],"genre_scores_gemma":[0.998022,0.0003088329,0.00100237,0.0001080457,0.00009652485,0.00006033855,0.0001346458,0.0000217597,0.0002454495],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.02231747,"threshold_uncertainty_score":0.4131294,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.009596341111914342,"score_gpt":0.229807777661763,"score_spread":0.2202114365498486,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}