{"id":"W4392004363","doi":"10.1128/msphere.00804-23","title":"Manganese homeostasis modulates fungal virulence and stress tolerance in <i>Candida albicans</i>","year":2024,"lang":"en","type":"article","venue":"mSphere","topic":"Tryptophan and brain disorders","field":"Neuroscience","cited_by":11,"is_retracted":false,"has_abstract":true,"ca_institutions":"Université de Montréal; Université Laval; Montreal Heart Institute","funders":"Natural Sciences and Engineering Research Council of Canada; Canadian Institutes of Health Research; Fonds de recherche du Québec; Julius-Maximilians-Universität Würzburg; Canada Foundation for Innovation","keywords":"Virulence; Candida albicans; Microbiology; Homeostasis; Biology; Manganese; Cell biology; Chemistry; Genetics","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00009316859,0.0002687472,0.0002915618,0.000223776,0.0002384296,0.0005459223,0.0002536626,0.0002430511,0.0008984623],"category_scores_gemma":[0.0001166145,0.0001089734,0.0002189119,0.0002238641,0.0001719313,0.0001366286,0.0002429102,0.0005320954,0.0002549303],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004323703,"about_ca_system_score_gemma":0.0002348786,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00286467,"about_ca_topic_score_gemma":0.003386833,"domain_scores_codex":[0.9998484,0.00001583312,0.0000125969,0.00004505225,0.00004018591,0.00003791906],"domain_scores_gemma":[0.999908,0.000008976755,0.00002514682,0.000008546121,0.00002476607,0.00002453655],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001249174,0.0000140448,0.0006977781,0.00003502445,0.000004219209,0.00003557774,0.00001098183,0.00004067005,0.9980652,0.00002792252,0.0001175503,0.0008261992],"study_design_scores_gemma":[0.00001690286,0.000334628,0.07875004,0.00003097748,0.00004137832,0.0003400036,0.000184768,0.002410999,0.9125758,0.0001278046,0.005158416,0.00002834878],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9945733,0.001278954,0.000891678,0.0001796039,0.0000354391,0.00002081893,0.001765373,0.0001153411,0.001139455],"genre_scores_gemma":[0.9954005,0.0004609396,0.0008345436,0.0001376077,0.0000130665,0.0000247434,0.001446522,0.00003146444,0.001650696],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.00286467,"threshold_uncertainty_score":0.005695999,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01208273360135677,"score_gpt":0.2409267660420654,"score_spread":0.2288440324407087,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}