{"id":"W4392005706","doi":"10.1016/j.isci.2024.109293","title":"Dysregulated lysosomal exocytosis drives protease-mediated cartilage pathogenesis in multiple lysosomal disorders","year":2024,"lang":"en","type":"article","venue":"iScience","topic":"Zebrafish Biomedical Research Applications","field":"Biochemistry, Genetics and Molecular Biology","cited_by":11,"is_retracted":false,"has_abstract":true,"ca_institutions":"Université de Montréal; Centre Hospitalier de l’Université de Montréal","funders":"National Institute of General Medical Sciences; National Institutes of Health; National Institute of Neurological Disorders and Stroke; National MPS Society","keywords":"Exocytosis; Cathepsin B; Lysosome; Cell biology; Cathepsin; Pathogenesis; Proteases; Cartilage; Biology; Cathepsin S; Chemistry; Immunology; Secretion; Biochemistry; Enzyme; Anatomy","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003102455,0.0001584211,0.0001191264,0.0001636756,0.0001198451,0.00008763942,0.0004666806,0.0001419208,0.00004530816],"category_scores_gemma":[0.0006627609,0.0001402753,0.00007842518,0.001034006,0.0005478806,0.00001742214,0.0002288439,0.0001276434,0.00009196705],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00003986319,"about_ca_system_score_gemma":0.0002849167,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00006518482,"about_ca_topic_score_gemma":0.0004633975,"domain_scores_codex":[0.998082,0.00008188474,0.000232701,0.0006913734,0.000398552,0.0005134192],"domain_scores_gemma":[0.9992301,0.00007205456,0.0000285002,0.0003853385,0.00004484574,0.0002391056],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00001885409,0.00008416444,0.007086242,0.00002263598,0.000006603886,0.00001628185,0.00006387899,0.00002290928,0.982068,0.0000478418,0.000444809,0.01011777],"study_design_scores_gemma":[0.0008347551,0.000359557,0.1257536,0.0001016218,0.0000151942,0.00002011673,0.000212734,0.01703433,0.8038211,0.0003905866,0.05085073,0.0006057146],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9947888,0.001312891,0.001558712,0.001206111,0.00007847369,0.0005276449,0.00008593966,0.00006461972,0.0003767617],"genre_scores_gemma":[0.9984197,0.0001601555,0.0005053236,0.00009277448,0.00007083175,0.000319247,0.0001134534,0.00002122031,0.0002973103],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.1782469,"threshold_uncertainty_score":0.5720261,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01220828181755825,"score_gpt":0.2690967886978595,"score_spread":0.2568885068803013,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}