{"id":"W4392013129","doi":"10.3390/cells13050371","title":"H2S Protects from Rotenone-Induced Ferroptosis by Stabilizing Fe-S Clusters in Rat Cardiac Cells","year":2024,"lang":"en","type":"article","venue":"Cells","topic":"Sulfur Compounds in Biology","field":"Biochemistry, Genetics and Molecular Biology","cited_by":20,"is_retracted":false,"has_abstract":true,"ca_institutions":"Laurentian University","funders":"Natural Sciences and Engineering Research Council of Canada; Heart and Stroke Foundation of Canada","keywords":"Rotenone; Mitochondrion; Intracellular; Cell biology; Oxidative stress; Cytosol; Programmed cell death; Lipid peroxidation; Chemistry; Reactive oxygen species; Deferiprone; Deferoxamine; Biology; Apoptosis; Biochemistry; Enzyme","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.0002388732,0.0002814076,0.0002949721,0.00007770736,0.00005366022,0.00007528367,0.0003169411,0.0003909772,0.00004310259],"category_scores_gemma":[0.00003365051,0.0002740585,0.0001555109,0.0001824996,0.00007822681,0.000006662818,0.0002381511,0.0002811316,0.0001177365],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00008817856,"about_ca_system_score_gemma":0.0001055376,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001851242,"about_ca_topic_score_gemma":0.0000394093,"domain_scores_codex":[0.9980939,0.0002246516,0.0003012175,0.0007969696,0.0001315542,0.0004517032],"domain_scores_gemma":[0.9991977,0.00007372653,0.00005043881,0.0005411765,0.00003533627,0.0001016652],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00004786643,0.00003572836,0.0001628372,0.00003637973,0.00006178513,0.0000139893,0.000139928,0.00003454361,0.9903914,0.000002269969,0.007390035,0.001683264],"study_design_scores_gemma":[0.0002814993,0.0001484672,0.00003195761,0.00004614922,0.00001708237,0.000001395499,0.0001579306,0.0001538712,0.9451514,0.00004510143,0.05364736,0.0003177735],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9918684,0.003854322,0.0003142705,0.0001708791,0.002293035,0.0005878292,0.0000883637,0.00005197485,0.0007709065],"genre_scores_gemma":[0.9975001,0.0002726751,0.0007277068,0.0002120557,0.0003462982,0.0001015783,0.0001960112,0.00006115798,0.0005824413],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.04625732,"threshold_uncertainty_score":0.9999712,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01246714732317519,"score_gpt":0.2423681539582711,"score_spread":0.2299010066350959,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}