{"id":"W4392015136","doi":"10.1056/nejmoa2312100","title":"A Phase 3 Trial of Seladelpar in Primary Biliary Cholangitis","year":2024,"lang":"en","type":"article","venue":"New England Journal of Medicine","topic":"Liver Diseases and Immunity","field":"Medicine","cited_by":235,"is_retracted":false,"has_abstract":true,"ca_institutions":"University Health Network","funders":"CymaBay Therapeutics","keywords":"Agonist; Gastroenterology; Internal medicine; Medicine; Primary (astronomy); Receptor; Physics","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001891373,0.001002832,0.001818327,0.0003693969,0.0004575926,0.0007052113,0.0005716011,0.001328317,0.007673409],"category_scores_gemma":[0.001443293,0.0004015541,0.001380413,0.000336432,0.0008260278,0.0005718038,0.0003505624,0.002527995,0.001082155],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003867093,"about_ca_system_score_gemma":0.001238001,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000456302,"about_ca_topic_score_gemma":0.001174055,"domain_scores_codex":[0.9994204,0.0003517315,0.00002839473,0.00005880221,0.00005064738,0.00009014056],"domain_scores_gemma":[0.9989956,0.0002871938,0.0002211731,0.00007787265,0.00007566891,0.0003425463],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"randomized_trial","study_design_scores_codex":[0.927176,0.01693891,0.001677061,0.001150285,0.0007632084,0.0002019037,0.0001247486,0.0005023638,0.009026889,0.0001728783,0.002493796,0.03977203],"study_design_scores_gemma":[0.9049252,0.09129846,0.002068425,0.00002807967,0.0001344849,0.0001062883,0.00002101763,0.0001918963,0.0005023153,0.00008862618,0.0006272171,0.000008002452],"study_design_candidate":"randomized_trial","study_design_consensus":"randomized_trial","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9868171,0.004091165,0.0006777602,0.001325226,0.0003652981,0.003574218,0.0008204964,0.0001735173,0.00215535],"genre_scores_gemma":[0.982686,0.003031492,0.001990973,0.002203686,0.0004337575,0.006141629,0.001128517,0.00003502121,0.002348914],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.007673409,"threshold_uncertainty_score":0.02567011,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02557010079253616,"score_gpt":0.3226086206326299,"score_spread":0.2970385198400937,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}